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The genomic and clinical consequences of replacing procarbazine with dacarbazine in escalated BEACOPP for Hodgkin lymphoma: a retrospective, observational study
The Lancet Oncology ( IF 41.6 ) Pub Date : 2024-12-12 , DOI: 10.1016/s1470-2045(24)00598-9 Anna Santarsieri MD, Emily Mitchell PhD, My H Pham MPhil, Rashesh Sanghvi MSc, Janina Jablonski MSc, Henry Lee-Six PhD, Katherine Sturgess PhD, Pauline Brice PhD, Tobias F Menne PhD, Wendy Osborne MD, Thomas Creasey PhD, Kirit M Ardeshna MD, Joanna Baxter PhD, Sarah Behan DipHE, Kaljit Bhuller MD, Stephen Booth MD, Nikesh D Chavda MD, Prof Graham P Collins PhD, Dominic J Culligan MD, Kate Cwynarski PhD, Prof Andrew Davies PhD, Abigail Downing MD, David Dutton MD, Michelle Furtado PhD, Eve Gallop-Evans PhD, Andrew Hodson MD, David Hopkins MD, Hannah Hsu MD, Sunil Iyengar PhD, Stephen G Jones MD, Mamatha Karanth MD, Kim M Linton PhD, Oliver C Lomas PhD, Nicolas Martinez-Calle PhD, Abhinav Mathur MD, Pamela McKay MD, Sateesh K Nagumantry MD, Elizabeth H Phillips MD, Neil Phillips MD, Prof John F Rudge PhD, Nimish K Shah MD, Gwyneth Stafford BSc, Alex Sternberg MD, Rachel Trickey MD, Benjamin J Uttenthal PhD, Natasha Wetherall MD, Xiao-Yin Zhang MD, Andrew K McMillan PhD, Prof Nicholas Coleman PhD, Prof Michael R Stratton PhD, Elisa Laurenti PhD, Prof Peter Borchmann PhD, Sven Borchmann PhD, Peter J Campbell PhD, Raheleh Rahbari PhD, Prof George A Follows PhD
The Lancet Oncology ( IF 41.6 ) Pub Date : 2024-12-12 , DOI: 10.1016/s1470-2045(24)00598-9 Anna Santarsieri MD, Emily Mitchell PhD, My H Pham MPhil, Rashesh Sanghvi MSc, Janina Jablonski MSc, Henry Lee-Six PhD, Katherine Sturgess PhD, Pauline Brice PhD, Tobias F Menne PhD, Wendy Osborne MD, Thomas Creasey PhD, Kirit M Ardeshna MD, Joanna Baxter PhD, Sarah Behan DipHE, Kaljit Bhuller MD, Stephen Booth MD, Nikesh D Chavda MD, Prof Graham P Collins PhD, Dominic J Culligan MD, Kate Cwynarski PhD, Prof Andrew Davies PhD, Abigail Downing MD, David Dutton MD, Michelle Furtado PhD, Eve Gallop-Evans PhD, Andrew Hodson MD, David Hopkins MD, Hannah Hsu MD, Sunil Iyengar PhD, Stephen G Jones MD, Mamatha Karanth MD, Kim M Linton PhD, Oliver C Lomas PhD, Nicolas Martinez-Calle PhD, Abhinav Mathur MD, Pamela McKay MD, Sateesh K Nagumantry MD, Elizabeth H Phillips MD, Neil Phillips MD, Prof John F Rudge PhD, Nimish K Shah MD, Gwyneth Stafford BSc, Alex Sternberg MD, Rachel Trickey MD, Benjamin J Uttenthal PhD, Natasha Wetherall MD, Xiao-Yin Zhang MD, Andrew K McMillan PhD, Prof Nicholas Coleman PhD, Prof Michael R Stratton PhD, Elisa Laurenti PhD, Prof Peter Borchmann PhD, Sven Borchmann PhD, Peter J Campbell PhD, Raheleh Rahbari PhD, Prof George A Follows PhD
Procarbazine-containing chemotherapy regimens are associated with cytopenias and infertility, suggesting stem-cell toxicity. When treating Hodgkin lymphoma, procarbazine in escalated-dose bleomycin–etoposide–doxorubicin–cyclophosphamide–vincristine–procarbazine–prednisolone (eBEACOPP) is increasingly replaced with dacarbazine (eBEACOPDac) to reduce toxicity. We aimed to investigate the impact of this drug substitution on the mutation burden in stem cells, patient survival, and toxicity.
中文翻译：
用达卡巴嗪替代丙卡巴肼治疗霍奇金淋巴瘤升级的 BEACOPP 的基因组学和临床后果：一项回顾性观察性研究
含丙卡巴肼的化疗方案与血细胞减少和不孕有关，提示干细胞毒性。在治疗霍奇金淋巴瘤时，递增剂量博来霉素-依托泊苷-多柔比星-环磷酰胺-长春新碱-丙卡巴肼-泼尼松龙 （eBEACOPP） 中的丙卡巴嗪越来越多地被达卡巴嗪 （eBEACOPDac） 取代以降低毒性。我们旨在研究这种药物替代对干细胞突变负荷、患者生存和毒性的影响。
更新日期：2024-12-12
中文翻译：
用达卡巴嗪替代丙卡巴肼治疗霍奇金淋巴瘤升级的 BEACOPP 的基因组学和临床后果：一项回顾性观察性研究
含丙卡巴肼的化疗方案与血细胞减少和不孕有关，提示干细胞毒性。在治疗霍奇金淋巴瘤时，递增剂量博来霉素-依托泊苷-多柔比星-环磷酰胺-长春新碱-丙卡巴肼-泼尼松龙 （eBEACOPP） 中的丙卡巴嗪越来越多地被达卡巴嗪 （eBEACOPDac） 取代以降低毒性。我们旨在研究这种药物替代对干细胞突变负荷、患者生存和毒性的影响。
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