The iridium-catalyzed asymmetric hydrogenation of α-alkoxy-β-ketoesters via dynamic kinetic resolution has been achieved with high efficiency and enantioselectivity. This strategy allows for the synthesis of differentiated anti-1,2-diol derivatives in high yields, exhibiting excellent enantio- and diastereoselectivity (up to 99% yield, 99% ee, and 99 : 1 dr). Additionally, high turnover number (TON) experiments (up to 1000 TON) and gram-scale synthesis of a key fragment of the potential drug Tesaglitazar were successfully performed, highlighting the protocol's potential for broader applications.

中文翻译：

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通过 Ir 催化的 α-烷氧基-β-酮酯的不对称氢化轻松获得手性抗 1,2-二醇衍生物


通过动态动力学分辨率实现铱催化的 α-烷氧基-β-酮酯的不对称氢化，具有很高的效率和对映选择性。该策略允许以高产率合成差异化的抗 1,2-二醇衍生物，表现出优异的对映和非对映选择性（高达 99% 的产率、99% 的 ee 和 99 ： 1 dr）。此外，成功进行了高周转数 （TON） 实验（高达 1000 TON）和潜在药物 Tesaglitazar 关键片段的克级合成，突出了该方案具有更广泛应用的潜力。