Background and Hypotheses The lack of psychometrically validated assessment tools designed specifically to assess negative symptoms in individuals at clinical high risk (CHR) for psychosis represents a significant barrier to the early identification and prevention of psychosis. To address this need, the Negative Symptom Inventory-Psychosis Risk (NSI-PR) was developed based on the iterative, data-driven approach recommended by the National Institute of Mental Health consensus conference on negative symptoms. Study Design This manuscript reports the results of the second study phase that psychometrically validates the final 11-item version of the scale in data collected across 3 sites. A total of 222 participants (144 CHR and 78 clinical help-seeking controls) completed the NSI-PR, 1 week of ecological momentary assessment (EMA), and additional convergent and discriminant validity measures. Study Results Structural analyses replicated the previously reported strong fit for the 5-factor (anhedonia, avolition, asociality, alogia, and blunted affect) and hierarchical structures (2 super-ordinate dimensions and 5 lower-level domains). The 5 domains and 2 dimensions generally demonstrated good internal consistency, temporal stability, and interrater reliability. Convergent validity was demonstrated in relation to the 16-item beta version of the NSI-PR, Structured Interview for Psychosis-risk Syndromes negative subscale, Global Functioning Scale social and role, and EMA measures. Discriminant validity was supported by low correlations with positive, disorganized, and general psychiatric symptoms. Conclusions Findings indicate the final 11-item version of the NSI-PR has sound psychometric properties. The scale, which is designed specifically for CHR individuals, is brief and appropriate for use in research and clinical contexts. Accompanying training materials have been developed to support its use in multisite trials.

中文翻译：

---

阴性症状量表-精神病风险 （NSI-PR）：最终 11 项版本的心理测量验证


背景和假设 缺乏经过心理测量验证的评估工具，专门用于评估精神病临床高风险 （CHR） 个体的阴性症状，这是早期识别和预防精神病的重大障碍。为了满足这一需求，阴性症状清单-精神病风险 （NSI-PR） 是根据美国国家心理健康研究所关于阴性症状共识会议推荐的迭代、数据驱动方法开发的。研究设计 这份手稿报告了第二研究阶段的结果，该阶段在心理测量学上验证了在 3 个地点收集的数据中量表的最终 11 项版本。共有 222 名参与者 （144 名 CHR 和 78 名临床求助对照） 完成了 NSI-PR、1 周的生态瞬时评估 （EMA） 以及其他收敛和判别有效性措施。研究结果 结构分析复制了先前报道的 5 因素 （快感缺乏、 avolition、 非社会性、 失语症和钝化情感） 和层次结构 （2 个上级维度和 5 个较低级别域） 的强拟合。5 个领域和 2 个维度通常表现出良好的内部一致性、时间稳定性和评分者间可靠性。与 NSI-PR 的 16 项测试版、精神病风险综合征结构化访谈阴性分量表、全球功能量表社会和角色以及 EMA 测量相关的收敛效度得到证明。与阳性、杂乱无章和一般精神症状的低相关性支持判别效度。结论 研究结果表明，NSI-PR 的最终 11 项版本具有良好的心理测量特性。 该量表专为 CHR 个体设计，简短且适用于研究和临床环境。已经开发了随附的培训材料，以支持其在多中心试验中的使用。