BACKGROUND People with HIV (PWH) experience a higher burden of ageing-associated comorbidities, the underlying mechanisms of which remain to be fully elucidated. We aimed to identify profiles based on immune, inflammatory, and ageing biomarkers in blood from PWH and controls, and explore their association with total comorbidities over time. METHODS Latent profile analysis was used to construct biomarker profiles in AGEhIV cohort participants (94 with well-controlled HIV on antiretroviral therapy (ART) and 95 controls without HIV) using baseline measurements of selected biomarkers. Factors associated with profile membership were assessed by multivariable logistic regression. The association between profiles and mean total comorbidities during follow-up was assessed by Poisson regression, stratified by HIV-status. Comorbidities included type 2 diabetes, non-AIDS malignancies, cardiovascular disease, osteoporosis, chronic kidney disease and frailty. RESULTS Three biomarker profiles were identified: 'High Thymic Output/Low Inflammation' (HT/LI) profile (n=27 PWH, n=9 controls), 'Low Thymic Output/High Inflammation' (LT/HI) profile (n=29 PWH, n=26 controls), and an 'Intermediate' profile (n=38 PWH, n=60 controls). Only HIV-status was significantly associated with profile membership. PWH, relative to controls, more often exhibited the HT/LI profile compared to other profiles. In PWH, but not in controls, the HT/LI profile was associated with significantly lower mean comorbidities during a median 8.0 years (IQR=7.1-8.1) of follow-up. CONCLUSIONS People ageing with well-controlled HIV on ART were more likely to exhibit a biomarker profile indicative of preserved thymic function and less chronic inflammation compared to controls. PWH with such a profile seemed relatively protected from developing ageing-associated comorbidities.

中文翻译：

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反映保留胸腺功能的生物标志物谱与老年 HIV 感染者合并症减少相关：AGEhIV 队列分析。


背景 HIV 感染者 （PWH） 承受着更高的老龄化相关合并症负担，其潜在机制仍有待完全阐明。我们旨在根据 PWH 和对照血液中的免疫、炎症和衰老生物标志物来确定概况，并探索它们与随时间推移的总合并症的关联。方法 使用选定生物标志物的基线测量，使用潜在谱分析构建 AGEhIV 队列参与者 （94 名接受抗逆转录病毒治疗 （ART） 的 HIV 控制良好，95 名无 HIV 的对照者）的生物标志物谱。通过多变量 logistic 回归评估与概况成员相关的因素。通过泊松回归评估随访期间概况与平均总合并症之间的关联，按 HIV 状态分层。合并症包括 2 型糖尿病、非 AIDS 恶性肿瘤、心血管疾病、骨质疏松症、慢性肾病和虚弱。结果确定了三种生物标志物谱：“高胸腺输出量/低炎症”（HT/LI） 谱（n=27 PWH，n=9 对照）、“低胸腺输出量/高炎症”（LT/HI） 谱（n=29 PWH，n=26 对照）和“中间”谱（n=38 PWH，n=60 对照）。只有 HIV 状态与个人资料成员身份显著相关。与其他特征相比，相对于对照组，PWH 更常表现出 HT/LI 特征。在 PWH 中，但在对照组中，HT/LI 谱与中位 8.0 年 （IQR=7.1-8.1） 随访期间平均合并症显著降低相关。结论 与对照组相比，ART 上 HIV 控制良好的老年人更有可能表现出表明胸腺功能保留和慢性炎症较少的生物标志物谱。 具有这种特征的 PWH 似乎相对不受保护，不会发生与衰老相关的合并症。