In the marine environment, various weathering effects on micro or nanoplastics lead to surface modifications, which in turn alter their toxic effects on aquatic organisms. This study investigated the impact of three types of nanoplastics (NPs, NPs-NH2, NPs-COOH) on the antioxidant capacity of Mytilus coruscus gills, mantle, and hemolymph over 28 days. Analyzed key antioxidant stress indicators (CAT, SOD, GSH, GSH-Px, MDA, H2O2) and conducted IBR and PCA analyses to evaluate the toxic effects of modified nanoplastics. In particular, NPs-NH2 showed the most significant inhibition of antioxidant enzymes like CAT and GSH-Px in gills and mantle, while NPs-COOH affected a wider range of oxidative stress markers. Furthermore, tissue-specific responses were observed, with gills being the most sensitive to biomarker changes. Overall, NPs-NH2 emerged as the most toxic nanoplastic, highlighting the need to assess ecological risks associated with novel nanoparticles in marine environments and offering insights into tissue-specific toxicity in mussels.

中文翻译：

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功能化纳米塑料对贻贝 Mytilus coruscus 氧化应激的影响


在海洋环境中，微塑料或纳米塑料的各种风化作用会导致表面改性，进而改变它们对水生生物的毒性作用。本研究调查了三种纳米塑料 （NPs、NPs-NH2、NPs-COOH） 在 28 天内对 Mytilus coruscus 鳃、外套膜和血淋巴液抗氧化能力的影响。分析关键抗氧化胁迫指标 （CAT、SOD、GSH、GSH-Px、MDA、H2O2） 并进行 IBR 和 PCA 分析，以评估改性纳米塑料的毒性作用。特别是，NPs-NH2 对鳃和外套膜中 CAT 和 GSH-Px 等抗氧化酶的抑制作用最显着，而 NPs-COOH 影响更广泛的氧化应激标志物。此外，观察到组织特异性反应，其中鳃对生物标志物变化最敏感。总体而言，NPs-NH2 成为毒性最强的纳米塑料，突出了评估与海洋环境中新型纳米颗粒相关的生态风险的必要性，并提供了对贻贝组织特异性毒性的见解。