This article describes the development of a stable and reusable diatomic cobalt catalyst for the synthesis of various quinazoline derivatives via the dehydrogenation cyclization reaction of anthranilic alcohol with amidine in a simple and environmental friendly manner. Crystallographic studies reveal that the superior catalytic reactivity can be attributed to the synergistic cooperation between the adjacent cobalt active centers within a confined domain for the co-adsorption and co-activation of substrates. This work provides new insights into the application of heterogeneous catalysts in organic synthesis.

中文翻译：

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双原子钴催化邻氨基苯甲醇与脒的环化反应，用于合成喹唑啉


本文介绍了一种稳定且可重复使用的双原子钴催化剂的开发，用于通过邻氨基苯甲酸与脒的脱氢环化反应以简单环保的方式合成各种喹唑啉衍生物。晶体学研究表明，优异的催化反应性可归因于受限域内相邻钴活性中心之间的协同合作，以实现底物的共吸附和共活化。这项工作为非均相催化剂在有机合成中的应用提供了新的见解。