The role of proteases in cartilage degradation and the development of osteoarthritis is undeniable. Despite over two decades of research on protease inhibitors, however, the transition from preclinical promise to clinical success remains elusive, underscoring the urgent need to critically appraise the challenges and limitations inherent in preclinical studies.

中文翻译：

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评估骨关节炎中蛋白酶抑制的不断发展前景


蛋白酶在软骨降解和骨关节炎发展中的作用是不可否认的。然而，尽管对蛋白酶抑制剂进行了二十多年的研究，但从临床前希望到临床成功的转变仍然难以捉摸，这凸显了批判性评估临床前研究中固有的挑战和局限性的迫切需要。