Chiral nanomaterials are emerging as a promising class of vaccine adjuvants with the potential to significantly enhance vaccine efficacy, especially in the context of cancer immunotherapy. These nanomaterials can trigger enantioselective immune responses, enabling more precise and efficient vaccines. Their distinctive optical, electronic, and catalytic characteristics, along with the ability to be engineered with specific physical and chemical properties, make them highly suitable for next-generation vaccines development. Chiral nanomaterials can enhance antigen presentation, modulate the tumor microenvironment, and boost the efficacy of immune responses, particularly against complex diseases such as cancer. Nevertheless, significant challenges remain, such as ensuring the reproducibility of their synthesis, conducting thorough safety assessments, and gaining a deeper understanding of their interactions with the immune system. Continued research and development are crucial to unlocking the potential of chiral nanomaterials in vaccine technology, thus paving the way for more effective, targeted, and personalized immunotherapies.

中文翻译：

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手性纳米材料作为疫苗佐剂：免疫治疗的新视野


手性纳米材料正在成为一类有前途的疫苗佐剂，有可能显著提高疫苗效力，尤其是在癌症免疫治疗的背景下。这些纳米材料可以触发对映选择性免疫反应，从而实现更精确、更高效的疫苗。它们独特的光学、电子和催化特性，以及具有特定物理和化学特性的能力，使其非常适合下一代疫苗的开发。手性纳米材料可以增强抗原呈递，调节肿瘤微环境，并提高免疫反应的功效，特别是针对癌症等复杂疾病。然而，仍然存在重大挑战，例如确保其合成的可重复性、进行彻底的安全性评估以及更深入地了解它们与免疫系统的相互作用。持续的研究和开发对于释放手性纳米材料在疫苗技术中的潜力至关重要，从而为更有效、更有针对性和个性化的免疫疗法铺平道路。