Section snippets

Study design and setting

This retrospective cohort includes all patients admitted for RHD surgery at the Salam Centre from April 2007 to December 2021, with follow-up of patients discharged alive evaluated up to July 2022. The Salam Centre⁷ admits about 80% of patients from Sudan and 20% from neighboring countries, as per agreement with the government. The hospital was built and is managed by the NGO, EMERGENCY, which supplies equipment, prosthetic valves, drugs, technical support, national and international staffing,

Results

From 2007 to 2021, 7,449 patients with RHD underwent single (N = 3,879: mitral valve [MV], n = 3,043; aortic valve [AV], n = 829; tricuspid valve [TV], n = 7), double (N = 2,856: MV + AV, n = 1,472; MV + TV, n = 1,380; TV + AV, n = 4), or triple (N = 714 MV + AV + TV) valve surgeries, of 9,506 open-heart procedures at the Salam Centre. Principal characteristics and patient outcomes are reported in Table 1. The mean age of patients was 25 years, with 20% <15 years of age, and a mean body mass

Discussion

The Salam Centre experience summarizes outcomes for early- and late-surgical mortality for 7,449 patients undergoing valvular surgery for RHD. This is the largest cohort of RHD surgical patients in SSA and our findings extend the knowledge of pathophysiology and surgical management of rheumatic valvular disease in SSA. Although delivering care to a small percentage of affected patients, the Salam experience offers a model demonstrating feasibility, affordability, high-volume activity, and

Funding Support and Author Disclosures

The authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Acknowledgments

The authors’ work is dedicated to our patients who are displaced because of the ongoing conflict and may have interrupted treatments. This project was supported by too many institutions, friends, supporters, and donors to mention all of them! Our founder, Gino Strada, has been chief surgeon for many years; his enthusiasm and expertise remain our cornerstone. The deidentified data of patients that underlie the results reported in this paper (text, tables, figures, and supplemental material) and

中文翻译：

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苏丹风湿性瓣膜手术：Salam 心脏外科中心对 7,449 名患者进行了检测

 部分片段

 研究设计和设置

该回顾性队列包括 2007 年 4 月至 2021 年 12 月在 Salam 中心接受 RHD 手术的所有患者，并对存活出院的患者进行了随访评估，评估了截至 2022 年 7 月。根据与政府的协议，Salam Centre⁷ 接收了大约 80% 的苏丹患者和 20% 的邻国患者。该医院由非政府组织 EMERGENCY 建造和管理，该组织提供设备、人工瓣膜、药物、技术支持、国内和国际人员配备。

 结果

从 2007 年到 2021 年，7,449 例 RHD 患者接受了单瓣（N = 3,879：二尖瓣 [MV]，n = 3,043;主动脉瓣 [AV]，n = 829;三尖瓣 [TV]，n = 7）、双瓣（N = 2,856：MV + AV，n = 1,472;MV + TV，n = 1,380;TV + AV，n = 4）或三重 （n = 714 MV + AV + TV） 瓣膜手术，在 Salam 中心的 9,506 例心内直视手术中。主要特征和患者结果见表 1。患者的平均年龄为 25 岁，其中 20% <15 岁，平均体重

 讨论

Salam 中心的经验总结了 7,449 名接受 RHD 瓣膜手术的患者的早期和晚期手术死亡率结果。这是 SSA 中最大的 RHD 手术患者队列，我们的研究结果扩展了 SSA 风湿性瓣膜病的病理生理学和手术管理知识。尽管为一小部分受影响的患者提供护理，但 Salam 体验提供了一个模型，展示了可行性、可负担性、高容量活动和

资金支持和作者披露

作者报告说，他们与本文的内容没有要披露的关系。

 确认

作者的工作致力于我们的患者，他们因持续的冲突而流离失所，并可能中断了治疗。这个项目得到了太多机构、朋友、支持者和捐助者的支持，无法一一列举！我们的创始人 Gino Strada 多年来一直担任首席外科医生;他的热情和专业知识仍然是我们的基石。本文报告的结果所依据的患者去标识化数据（文本、表格、数字和补充材料）和