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Intraindividual Variability in Serial Lipoprotein(a) Concentrations Among Placebo-Treated Patients in the OCEAN(a)-DOSE Trial
Journal of the American College of Cardiology ( IF 21.7 ) Pub Date : 2024-12-11 , DOI: 10.1016/j.jacc.2024.10.081
Prakriti Gaba, Robert S. Rosenson, J. Antonio G. López, Gerald F. Watts, Thorsten M. Leucker, Julia F. Kuder, KyungAh Im, Helina Kassahun, Huei Wang, You Wu, Jingying Wang, E. Magnus Ohman, Marc S. Sabatine, Michelle L. O’Donoghue

Lipoprotein(a) [Lp(a)] is a presumed risk factor for atherosclerotic cardiovascular disease (ASCVD), and its levels are primarily genetically determined (∼70%-90%).1,2 As such, many guidelines and consensus groups recommend measuring Lp(a) levels only once in a person’s lifetime for risk stratification.3,4 However, data assessing the intraindividual variability of Lp(a) levels over time are limited.5, 6, 7

中文翻译:


在 OCEAN(a)-DOSE 试验中,安慰剂治疗患者系列脂蛋白 (a) 浓度的个体内变异性



脂蛋白 (a) [Lp(a)] 是动脉粥样硬化性心血管疾病 (ASCVD) 的假定危险因素,其水平主要由遗传决定 (∼70%-90%)。12 因此,许多指南和共识小组建议一个人一生中只测量一次 Lp(a) 水平以进行风险分层。34 然而,评估 Lp(a) 水平随时间变化的个体内变异性的数据是有限的。567
更新日期:2024-12-11
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