Polygenic scores (PGS) enable the exploration of pleiotropic effects and genomic dissection of complex traits. Here, in 421,889 individuals with European ancestry from the Million Veteran Program and UK Biobank, we examine how PGS of 17 neuropsychiatric traits are related to membership in 22 broad professional categories. Overall, we find statistically significant but weak (the highest odds ratio is 1.1 per PGS standard deviation) associations between most professional categories and genetic predisposition for at least one neuropsychiatric trait. Secondary analyses in UK Biobank revealed independence of these associations from observed fluid intelligence and sex-specific effects. By leveraging aggregate population trends, we identified patterns in the public interest, such as the mediating effect of education attainment on the association of attention-deficit/hyperactivity disorder PGS with multiple professional categories. However, at the individual level, PGS explained less than 0.5% of the variance of professional membership, and almost none after we adjusted for education and socio-economic status.

多基因评分 （PGS） 能够探索多效性效应和复杂性状的基因组解剖。在这里，在来自百万退伍军人计划和英国生物银行的 421,889 名具有欧洲血统的人中，我们研究了 17 种神经精神病学特征的 PGS 与 22 个广泛专业类别的成员资格有何关系。总体而言，我们发现大多数专业类别与至少一种神经精神病学特征的遗传易感性之间存在统计学显著但较弱的关联（最高比值比为每个 PGS 标准差 1.1）。英国生物样本库的二次分析显示，这些关联独立于观察到的液体智力和性别特异性影响。通过利用总体人口趋势，我们确定了符合公共利益的模式，例如教育程度对注意力缺陷/多动障碍 PGS 与多个专业类别关联的中介作用。然而，在个人层面，PGS 解释了不到 0.5% 的专业成员方差，在我们调整了教育和社会经济地位后，几乎没有解释。