Numerous contemporary diseases are linked to food contamination. Pathogenic agents might stem from certain food ingredients or result from pollution stemming from food processing or packaging. One such contaminant is 3‐Chloro‐1,2‐propanediol (3‐MCPD), it has been previously reported to be produced during the preparation of chemical sauces, as well as during the heating of baked goods. Yet, uncertainty surrounds its potential to induce embryonic developmental toxicity. In this study, zebrafish were employed as the focal point to assess the impact of 3‐MCPD on initial embryonic development, heart functionality, and behavior. The research unveiled that exposure of zebrafish embryos to 18, 36, and 54 mM 3‐MCPD led to cardiac anomalies, including pericardial edema, reduced heart rate, and elongated SV‐BA distance. Additionally, 3‐MCPD exposure triggered aberrations in cardiac‐related gene expression and an elevation in oxidative stress. Notably, behavioral changes were observed in 3‐MCPD‐exposed zebrafish embryos, while vascular development appeared unaffected. This study introduces a novel basis for comprehensive exploration of 3‐MCPD toxicity.

中文翻译：

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3-氯-1,2-丙二醇暴露会诱导斑马鱼胚胎的心脏毒性和行为异常


许多现代疾病都与食品污染有关。致病源可能来自某些食品成分，也可能由食品加工或包装产生的污染引起。其中一种污染物是 3-氯-1,2-丙二醇 （3-MCPD），以前有报道称它在制备化学酱汁以及加热烘焙食品期间产生。然而，其诱导胚胎发育毒性的可能性存在不确定性。在这项研究中，斑马鱼被用作评估 3-MCPD 对初始胚胎发育、心脏功能和行为影响的焦点。研究发现，斑马鱼胚胎暴露于 18、36 和 54 mM 3-MCPD 会导致心脏异常，包括心包水肿、心率降低和 SV-BA 距离延长。此外，3-MCPD 暴露引发心脏相关基因表达的异常和氧化应激的升高。值得注意的是，在 3-MCPD 暴露的斑马鱼胚胎中观察到行为变化，而血管发育似乎不受影响。本研究为全面探索 3-MCPD 毒性引入了新的基础。