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Current Advances in Viral Nanoparticles for Biomedicine
ACS Nano ( IF 15.8 ) Pub Date : 2024-12-09 , DOI: 10.1021/acsnano.4c13146
Xianxun Sun 1 , Tao Tian 1, 2 , Yindong Lian 1, 2 , Zongqiang Cui 2
ACS Nano ( IF 15.8 ) Pub Date : 2024-12-09 , DOI: 10.1021/acsnano.4c13146
Xianxun Sun 1 , Tao Tian 1, 2 , Yindong Lian 1, 2 , Zongqiang Cui 2
Affiliation
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Viral nanoparticles (VNPs) have emerged as crucial tools in the field of biomedicine. Leveraging their biological and physicochemical properties, VNPs exhibit significant advantages in the prevention, diagnosis, and treatment of human diseases. Through techniques such as chemical bioconjugation, infusion, genetic engineering, and encapsulation, these VNPs have been endowed with multifunctional capabilities, including the display of functional peptides or proteins, encapsulation of therapeutic drugs or inorganic particles, integration with imaging agents, and conjugation with bioactive molecules. This review provides an in-depth analysis of VNPs in biomedicine, elucidating their diverse types, distinctive features, production methods, and complex design principles behind multifunctional VNPs. It highlights recent innovative research and various applications, covering their roles in imaging, drug delivery, therapeutics, gene delivery, vaccines, immunotherapy, and tissue regeneration. Additionally, the review provides an assessment of their safety and biocompatibility and discusses challenges and future opportunities in the field, underscoring the vast potential and evolving nature of VNP research.
中文翻译:
生物医学用病毒纳米粒子的研究进展
病毒纳米颗粒 (VNP) 已成为生物医学领域的重要工具。利用其生物和物理化学特性,VNP 在预防、诊断和治疗人类疾病方面表现出显着优势。通过化学生物偶联、输注、基因工程和封装等技术,这些 VNP 已被赋予多功能能力,包括功能性肽或蛋白质的展示、治疗药物或无机颗粒的封装、与显像剂的整合以及与生物活性分子的偶联。本文对生物医学中的 VNPs 进行了深入分析,阐明了其多样化的类型、独特特征、生产方法和多功能 VNP 背后的复杂设计原理。它重点介绍了最近的创新研究和各种应用,涵盖了它们在成像、药物递送、治疗、基因递送、疫苗、免疫疗法和组织再生中的作用。此外,该综述还对其安全性和生物相容性进行了评估,并讨论了该领域的挑战和未来机遇,强调了 VNP 研究的巨大潜力和不断发展的性质。
更新日期:2024-12-09
中文翻译:

生物医学用病毒纳米粒子的研究进展
病毒纳米颗粒 (VNP) 已成为生物医学领域的重要工具。利用其生物和物理化学特性,VNP 在预防、诊断和治疗人类疾病方面表现出显着优势。通过化学生物偶联、输注、基因工程和封装等技术,这些 VNP 已被赋予多功能能力,包括功能性肽或蛋白质的展示、治疗药物或无机颗粒的封装、与显像剂的整合以及与生物活性分子的偶联。本文对生物医学中的 VNPs 进行了深入分析,阐明了其多样化的类型、独特特征、生产方法和多功能 VNP 背后的复杂设计原理。它重点介绍了最近的创新研究和各种应用,涵盖了它们在成像、药物递送、治疗、基因递送、疫苗、免疫疗法和组织再生中的作用。此外,该综述还对其安全性和生物相容性进行了评估,并讨论了该领域的挑战和未来机遇,强调了 VNP 研究的巨大潜力和不断发展的性质。