Established antiresorptive treatments for osteoporosis only slow down bone loss, and available osteoanabolic therapies — although more effective — have broad limitations. Recent insights into sex-specific systemic regulation of skeletal mass, an enhanced understanding of the cellular complexity of bone marrow and innovative options such as senolytics have fuelled the development of potentially transformative bone anabolic treatments.

中文翻译：

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调查新兴骨合成代谢疗法的前景


已建立的骨质疏松症抗骨吸收疗法只能减缓骨质流失，而现有的骨合成代谢疗法虽然更有效，但具有广泛的局限性。最近对骨骼质量的性别特异性全身调节的见解、对骨髓细胞复杂性的加深理解以及 senolytics 等创新选择推动了潜在变革性骨合成代谢治疗的发展。