Tranexamic acid versus placebo to prevent bleeding in patients with haematological malignancies and severe thrombocytopenia (TREATT): a randomised, double-blind, parallel, phase 3 superiority trial,The Lancet Haematology

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Tranexamic acid versus placebo to prevent bleeding in patients with haematological malignancies and severe thrombocytopenia (TREATT): a randomised, double-blind, parallel, phase 3 superiority trial
The Lancet Haematology ( IF 15.4 ) Pub Date : 2024-12-03 , DOI: 10.1016/s2352-3026(24)00317-x
TREATT Trial Investigators, Lise J Estcourt, Zoe K McQuilten, Peter Bardy, Merrole Cole-Sinclair, Graham P. Collins, Philip J. Crispin, Elinor Curnow, Jennifer Curnow, Amber Degelia, Claire Dyer, Adam Friebe, Lajos Floro, Effie Grand, Cara Hudson, Gail Jones, Joanne Joseph, Charlotte Kallmeyer, Marina Karakantza, Paul Kerr, Sara Last, Maria Lobo-Clarke, Matthew Lumley, Mary F McMullin, Patrick G. Medd, Suzy M. Morton, Andrew D. Mumford, Maria Mushkbar, Joseph Parsons, Gillian Powter, Mallika Sekhar, Laura Smith, Richard Soutar, William S. Stevenson, Elango Subramoniapillai, Jeff Szer, Helen Thomas, Neil A. Waters, Andrew H. Wei, David A. Westerman, Sarah A. Wexler, Erica M. Wood, Simon J. Stanworth, Adrienne Abioye, Rabia Afghan, Sylvia Ai Ai, Magbor Akanni, Rajesh Alajangi, Usmaan Alam, Bahaa Al-Bubseeree, Sophie Alderson, Craig Alderson, Sayed Ali, Kabir Ali, Rookmeen Alighan, Rebecca Allam Allam, Tania Allen, Wesam Al-Sakkaf, Kate Ames, Jacqueline Anderson, Colin Andrews, Ann-Marie Angel, Manuela Anlya Anlya, Farah Ansari, Rowan Appleby, Claire Arnold, Hulda Asbjornsdottir, Biruk Asfaw, Elissa Atkins, Leela Atkinson, Clare Aubrey, Noor Ayesha, Lola Babbola, David Badcock, Samuel Badcock, Diva Baggio, Ben Bailiff, Kizzy Baines, Holly Baker, Victoria Baker, Lindsay Ball, Martin Ball, Irwin Balquin, Emma Banks, George Banos, Jaytee Barnett, Claire Barrie, Claire Barron, Rebecca Barton, Nina Bason, Bindu Batta, Dianne Bautista, Angela Bayley, Emma Bayly, Fionnuala Baynes, Ali Bazargan, Rachel Bazeley, Yvonne Beadle, Claire Beardsmore, Kate Beattie, Kate Beattie, Caroline Bedford, Rachna Behal, Daniel Behan, Lilihna Bejan, Sarah Bell, Karen Bell, Louise Bell, Kaitlyn Bell, Reuben Benjamin, Sam Bennett, Gary Benson, Warwick Benson, Cameron Bent, Krystal Bergin, Alex Berry, Stephanie Besenyei, Caroline Besley, Scott Betteridge, Leigh Beveridge, Abir Bhattacharyya, Annelies Billen, Ian Bilmon, Emma Binns, Mark Birt, David Bishop, Andrea Blanco, Lisa Bleby, Richard Blemnerhet, Piers Blombery, Emily Blyth, Nicola Blythe, Lauren Boal, Ali Boden, Syed W.I. Bokhari, Elisa Bongetti, Stephen Booth, Jayne Borley, David Bowen, Dawn Bowers, Stephen Boyd, Sarah Bradley, Helen Bradman, Peta Bretag, Maria Brillante, Rachel Brockbank, Yasmin Brough, Ellen Brown, Jo Brown, Eleanor Brown, Claire Brown, Jenny Brown, Susan Brown, Joe Browning, Alex Brownsdon, David Bruce, Ruth Brydon-Hill, Andrea Buckwell, Dannielle Burgess, Glenda Burke, Kate Burley, Claire Burney, David Burns, Samuel Burrows, Kieran burton, Jason Butler, Lenka Cambalova, Maria C. Camozzi, Philip Campbell, Karen Campfield, Victoria Campion, Catherine Cargo, Julia Carmona, Dennis Carney, Joshua Casan, Helen Cashman, Lorraine Catt, Michael Cattell, Megan Cavill, Rachel Chadbone, Sridhar Chaganti, Yee Chai, Khai Li Chai, Joshua Chang, Judith Chapman, Oliver G. Chapman, Tamika Chapter, Andrew Charlton, Celina Chau, Saleena Chauhan, Nikesh Chavda, Frederick Chen, Melody Chen, Meng Xi Chen, Melanie Chen, Melissa Chen, Kathleen Cheok, Mai Cheung, Luke Chidgey, Karolina Chmielokliec, Philip Choi, Jae Choi, Anne Chok, Ruchika Chopra, Louise Christopherson, Vicky Chu, Chong Chyn Chua, Pavel Chudakou, Vidushi Chugh, Chi Chung, Erin Clark, Peter Clarke, Kathleen Clarke, Jennifer Clay, Laura Clayton, Mitch Clements, Jonathan Clemmens, Ruth Clifford, Dave Collett, Maia Collins, Emily Collyer, Maureen Connolly, Mark Cook, Sarah Coombs, Jason Coppell, Sophie Cornwell, Claire Corrigan, Elizabeth Coughlin, Jennifer Couling, Tony Cousins, Catriona Cowan, Christine Cox, Catherine Cox, Luke Coyle, Emily Craig, Thomas Creasey, Laura Croan, Jane Croft, Nicola Crosbie, Josephine Crowe, Helen Crowther, Jane Crozier, Naomi Culleton, Jonathan Cullis, Anita Cumming, Michelle Cummins, Adam Cunningham, Cameron Curley, Samantha Curtis, Robert Cuthbert, Kirsty Cuthill, Dinusha A Dahahayake, Amy Dang, Marc Davies, Ceri Davies, Emily Dawson, Tom Day, Kanchana De Abrew, Hugues De Lavallade, Neelaskshi De Silva, Georgina Dean, Christopher Deane, Lisa Demosthenous, Amisha Desai, Michael Desborough, Ian Devanny, Jay Dhanapal, Sundip Dhani, Vicky Di Martino, Emmy Dickens, Carmen DiCorleto, Louise Dinnett, Divya Dirisan, Karen Dixon, Kiri Dixon, Inderjit Doal, J Dobivh, Maria Docanto, Helve Doecke, David Donaldson, Kylee Donaldson, Carrie Donohoe, Ashley Douglas, Stephen Doung, Susan Downer, James D'Rozario, Malcolm Drummond, Mark Drummond, Samantha Drummond, Elizabeth Drysdale, Ross D'Souza, Eugene D'Souza, Alex Dunn, David Dutton, Martin Dyson, Kushani Ediriwicurena, Sharon Edleston, Dawn Edwards, Morgan Edwards, Anita Edwards, Nicole Eise, Steven Ellis, Hayley Ellis, Shareef Elmonley, Rosemarie Enstone, Agnes Eordogh, Sharon Erb, Shannon Evans, Megan Evans, Shannon Evans, Megan Evans, Joanne Ewing, Toby Eyre, Adam Facey, Mina Fammy, Jon Farman, Rachel Farnell, Laura Favero, Keith Fay, Karen Ferguson, Laura Fernon, Robin Filshie, Damian Finnegan, Lisa Fisher, Asia Flanagan, Emma Fleck, Simon Fletcher, Harpreet Flora, Catherine Flower, Ioana Fodor, Heather Foley, Emma Folland, Comfort Folorunso, Molly Forbes, Katrina Fordwor, Polly Foster, Vanessa Fox, Thomas Fox, Olesya Francis, Louise Fryearson, Madonna Fuery, Jiin Fung, Michelle Furtado, Leanne Galloway-Browne, Louise Gamble, Jeanette Gamgee, Arundathi Ganapathy, Hayley Gardner, Clare Gardner, Noha Gasmelsheed, Amy Gately, Lynda Gaynor, Alex Gebreid, Ruth Geffens, Rachel George, Aniko Gertner, Manar Ghebeh, Emanuela Ghirardini, Melainie Giddings, Sandra Gillett, Karen Gillett, Pratyush Giri, Chris Glass, Sarah Glewis, Sarah Gooding, Olivia Gordon, Joanne Gordon, David Gottlieb, Koushik Gowda, Elysie Gower, Nicola Gray, Jo Grayer, Elaine Greaves, Sally Anne Greenaway, Graeme Greenfield, Matthew Greenwood, Gareth Gregory, James Griffin, Julia Griffith, James Griffith, Lindsey Griffiths, Paulina Grzegrzolka, Yisu Gu, Jo Guest, Rosanna Guinai, Veena Gullapalli, A. Gunolr, Lina Guo, Wayne H, Sophia Hagua, Senait Haile, Richard Hall, Maryam Hamdollah-Zadeh, Zahra Hanif, Kathleen Hanlon, Nicholas Hann, Ramez Hanna, Guy Hannah, Sameera Hapuarachchi, Jacinta Hardman, Alison Hardy, Anthony Harris, Kylie Harris, Beth Harrison, Simon Harrison, Lea-Anne Harrison, Sean Harrop, Caroline Harvey, Faye Hatcliffe, Jo Hawking, Matthew Hawkins, Janet Hayden, Michelle Hayman, Elizabeth Haynes, Nicholas Heaney, Andrew Hebbard, Jenny Hempton, Sasanka Hendunneti, Maeve Henry, Jonathan Heywood, Catherine Hildyard, Lydia Hill, Annette Hilldrith, Petar Hitev, Smita Hiwase, Devendra Hiwase, Chris Hoare, Renate Hodge, Amy Holloway, Chloe Holt, Kelly Holton, Lauren Homer, Gillian Horne, Noemi Horvath, Linda Hotong, Kristen Houdyk, Katy Houseman, Ilda Hoxhallari, Hannah Hsu, Nina Hsu, Gillian Huang, Kerryn Hudson, Melanie Hufton, Timothy Hughes, Siobhan Hughes, Kate Hurley, Rosie Huxley, Temitope Ibitoye, Abubaken Ibrouf, Farha Inam, Tishya Indran, Karen Ingham, Calum Innes, David Irvine, Sarah Jaafar, Manish Jain, Laura Jameson, Pardeep Janjua, Rebecca Jarvis, Abirami Jatheendran, Abbie Javed, Sheila Jen, Shailesh Jobanpura, Irene Jobson, Deborah John, Sophie Johns, Amanda Johnston, Hollie Jones, Francesca Jones, Karolina Joniak, Michael Jovanovic, Anita Jovic, Lauren Joyce, Andrew Judd, Sudhakar Kakarlamudi, Nick Kakaroubas, Maggie Kalita, Shirly Kam, Julie Kan, P Kandle, Alex Kanellopoulos, Chien Kao, Maria Kaparou, Charamlampos Kartsios, Vicki Katsioulas, Russell Kaye, Katie Keen, Richard Kelly, Pauline Kelly, Donna Kelly, Melanie Kelly, Glen Kennedy, Nola Kennedy, Angela Kenny, Zoe Kenworthy, Ian Kerridge, Murali Kesavan, Angelika Khafizi, Muhammad Khakwani, Amna Khalid, Kate Khamly, Anjum Khan, Dalia Khan, Mojid Khan, Lubna Khan, Mona Khoo, Asim Khwaja, Grace Kim, Andrew King, Vicky King, Donna King, Francesca Kinsella, David Kipp, Pachoo Kirandeep, Laura C. Kirui, Bhuvan Kishore, Christopher Knectlhi, Amy Knot, Armit Knot, Cathy Ko, Caitlin Kolaric, Ray Koo, Mary Kotadia, Jaimal Kothari, Panagiotis D. 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Maqbool, Gregory Marchant, Mariana Marinho, David Marks, Mike Marner, Helen Marr, Gillian Marshall, Siobhan Martin, Abigail Martin, Maria Marzolini, Kiara Mason, Jonathan Massie, Rebecca Masson, Vidya Mathavan, Siju Mathew, Judith Mathie, Lehenta Mattocks, Bernard Maybury, Georgina Mayer, Chyrelle McAlister, Jo McAllister, Stewart McConnell, James McCracken, Liz McCullagh, Rory McCulloch, Christopher Mcdermott, Kerian Mcdonald, Laura McGinniss, Fiona McGurk, Jessica McIlwain, Kirsten McIver, Pam Mckay, Lorraine McKenna, Donal Mclornan, Coalon McMahon, Linda McNeice, Susan McNeill, Molly McNickle, Fiona McQueen, Simon McRae, Bobby McTaggart, Jenny Mehew, Varnn Mehra, Michelle Melly, Tara Menichelli, Ken Micklethwatte, Loredana Mihailescue, Aleksander Mijovic, Hannah Millband, Lucy Miller, Samuel T. 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Bleeding is common in patients with haematological malignancies undergoing intensive therapy. We aimed to assess the effect of tranexamic acid on preventing bleeding and the need for platelet transfusions.

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