The utilization of hydrogels in biomedical applications has been on the rise due to their capability to create a moist wound environment and composite with a diverse range of organic and mineral compounds. Our objective was to prepare a pH-responsive system with self-healing and excellent antibacterial properties, capable of releasing active agents at the wound site. Polyvinyl alcohol/tannic acid/thyme-honey/aloe vera hydrogels were synthesized through a freeze-thaw method and characterized for structural, chemical, morphological, antibacterial, and cytotoxicity properties. The hydrogels exhibited remarkable mechanical properties, including tensile strength ranging from 2.51 to 331.44 kPa and compression strength from 2.55 to 16.54 kPa, with viscoelastic behavior suitable for various body tissues. They demonstrated an average healing efficiency of 81 % within 10 min, enduring mechanical stress commonly encountered in wound dressings. The study evaluated their swelling behavior and pH responsiveness, revealing their potential for maintaining a well-hydrated wound environment. The release profiles of tannic acid, thyme-honey, and aloe vera were 82 %, 100 %, and 88 % within 23 days, respectively. The hydrogels demonstrated outstanding antibacterial efficacy, with an average inhibition rate exceeding 98 % against both E. coli and S. aureus, and up to 99 % with thyme-honey and aloe vera, enhancing cell proliferation capacity. Overall, the samples are non-toxic, antibacterial, and cost-effective, making them suitable for wound healing and drug delivery.

中文翻译：

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多功能刺激响应性自修复聚乙烯醇/单宁酸/百里香蜂蜜/芦荟水凝胶作为有前途的抗菌药物递送平台：物理化学和体外生物测定


水凝胶在生物医学应用中的利用率一直在上升，因为它们能够创造潮湿的伤口环境并与各种有机和矿物化合物复合。我们的目标是制备一种具有自修复和出色抗菌特性的 pH 响应系统，能够在伤口部位释放活性剂。聚乙烯醇/单宁酸/百里香蜂蜜/芦荟水凝胶通过冻融法合成，并表征了结构、化学、形态、抗菌和细胞毒性特性。水凝胶表现出显著的机械性能，拉伸强度为 2.51 至 331.44 kPa，压缩强度为 2.55 至 16.54 kPa，粘弹性为适用于各种身体组织。它们在 10 分钟内表现出 81% 的平均愈合效率，承受了伤口敷料中常见的机械应力。该研究评估了它们的肿胀行为和 pH 反应性，揭示了它们维持水分充足的伤口环境的潜力。单宁酸、百里香蜂蜜和芦荟在 23 天内的释放曲线分别为 82 %、100 % 和 88 %。水凝胶表现出出色的抗菌功效，对大肠杆菌和金黄色葡萄球菌的平均抑制率超过 98%，对百里香蜂蜜和芦荟的平均抑制率高达 99%，增强了细胞增殖能力。总体而言，这些样品无毒、抗菌且具有成本效益，使其适用于伤口愈合和药物输送。