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Serum GFAP and UCH-L1 for the identification of clinically important traumatic brain injury in children in France: a diagnostic accuracy substudy
The Lancet Child & Adolescent Health ( IF 19.9 ) Pub Date : 2024-12-02 , DOI: 10.1016/s2352-4642(24)00295-5
Antoine Puravet PharmD, Charlotte Oris PharmD PhD, Bruno Pereira PhD, Samy Kahouadji PharmD, Prof Philippe Gonzalo PharmD PhD, Prof Damien Masson PharmD PhD, Julie Durif MSc, Prof Catherine Sarret MD PhD, Prof Vincent Sapin PharmD PhD, Prof Damien Bouvier MD PhD

Many children with mild traumatic brain injury (mTBI), defined by a Glasgow Coma Scale (GCS) score between 13 and 15, undergo hospitalisation or cranial CT (CCT) scans despite the absence of clinically important traumatic brain injury (ciTBI; ie, hospitalisation >2 days associated with intracranial lesions on CCT, neurosurgical intervention, intensive care admission, or death). Clinical algorithms have reduced CCT scans and hospitalisations by 10%. We aimed to established age-appropriate reference values for GFAP and UCH-L1 and evaluate their diagnostic test performance in identifying ciTBI in children.

中文翻译:


血清 GFAP 和 UCH-L1 用于识别法国儿童临床上重要的创伤性脑损伤:诊断准确性子研究



许多轻度创伤性脑损伤 (mTBI) 患儿(定义为格拉斯哥昏迷量表 (GCS) 评分在 13 至 15 之间,尽管没有临床上重要的创伤性脑损伤 (ciTBI;即,与 CCT 颅内病变相关的住院 >2 天)、神经外科干预、重症监护入院或死亡,但仍接受了住院治疗或颅脑 CT (CCT) 扫描。临床算法已将 CCT 扫描和住院率减少了 10%。我们旨在建立适合年龄的 GFAP 和 UCH-L1 参考值,并评估它们在识别儿童 ciTBI 方面的诊断测试性能。
更新日期:2024-12-02
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