During 2023, approximately 72,000, or nearly seven in 10, drug overdose deaths in the United States were estimated to involve illegally manufactured fentanyls (IMFs). Carfentanil, a fentanyl analog 100 times more potent than fentanyl, has reemerged in the U.S. drug supply. Using CDC's State Unintentional Drug Overdose Reporting System data, this report describes trends in overdose deaths during January 2021-June 2024, overall and with IMFs detected, by U.S. Census Bureau region, and in deaths with carfentanil detected, in 45 states and the District of Columbia (DC). Numbers of deaths with carfentanil detected by state during January 2023-June 2024 in 49 states and DC are also reported. The number of overdose deaths with IMFs detected declined from 2022 to 2023 in the Northeast (3.2% decline), Midwest (7.8%), and South (2.8%) regions; deaths in the West increased 33.9%. The percentage of deaths with IMFs detected was steady at approximately 70%-80% in the Northeast, Midwest, and South. In contrast, the percentage of deaths with IMFs detected in the West increased from 48.5% during January-March 2021 to 66.5% during April-June 2024. Overdose deaths with carfentanil detected increased approximately sevenfold, from 29 during January-June 2023 to 238 during January-June 2024; during January 2023-June 2024, overdose deaths with carfentanil detected were reported in 37 states. Overdose prevention efforts that address the widespread presence of IMFs, including carfentanil, and can rapidly adapt to other potent opioids in the drug supply might result in lasting reductions in overdose deaths across the entire United States.

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药物过量死亡中非法制造的芬太尼和卡芬太尼的检测 - 美国，2021-2024 年。


2023 年，据估计，美国约有 72,000 人（或近十分之七）药物过量死亡涉及非法制造的芬太尼 （IMF）。卡芬太尼是一种效力是芬太尼 100 倍的芬太尼类似物，已重新出现在美国药品供应中。本报告使用 CDC 的州无意药物过量报告系统数据，描述了 2021 年 1 月至 2024 年 6 月期间美国人口普查局地区总体和 IMF 检测到的过量死亡趋势，以及 45 个州和哥伦比亚特区 （DC） 检测到的卡芬太尼死亡趋势。还报告了 2023 年 1 月至 2024 年 6 月期间在 49 个州和华盛顿特区发现的卡芬太尼死亡人数。从 2022 年到 2023 年，东北部（下降 3.2%）、中西部 （7.8%） 和南部 （2.8%） 地区检测到的 IMF 过量死亡人数有所下降;西部的死亡人数增加了 33.9%。在东北部、中西部和南部，检测到 IMF 的死亡百分比稳定在约 70%-80% 左右。相比之下，在西方检测到的 IMF 死亡百分比从 2021 年 1 月至 3 月的 48.5% 增加到 2024 年 4 月至 6 月的 66.5%。检测到的卡芬太尼过量死亡人数增加了约 7 倍，从 2023 年 1 月至 6 月的 29 人增加到 2024 年 1 月至 6 月的 238 人;2023 年 1 月至 2024 年 6 月期间，37 个州报告了因卡芬太尼过量死亡。解决 IMF（包括卡芬太尼）广泛存在的过量预防工作，并可以迅速适应药物供应中的其他强效阿片类药物，可能会导致整个美国的过量死亡人数持续减少。