Tumors utilize various mechanisms of HLA disruption in order to evade immune surveillance. Previous computational tools have interrogated specific aspects of this process, yet a holistic picture of HLA loss of heterozygosity (LOH), transcriptomic suppression, and alternative splicing has remained challenging. In a recent Nature Genetics study, Puttick and colleagues introduced MHC Hammer, a robust computational toolkit designed to dissect the complexities of HLA disruptions that mediate immune evasion in cancer. By analyzing comprehensive genomic and transcriptomic data across several large cancer cohorts, the study highlights the prevalence of HLA disruptions–particularly alternative splicing events–across various tumor types and identifies HLA LOH as an important immune evasion mechanism during metastasis in lung adenocarcinoma.

中文翻译：

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MHC-Hammer 解码肿瘤中的 HLA 破坏


肿瘤利用各种 HLA 破坏机制来逃避免疫监视。以前的计算工具已经询问了这个过程的特定方面，但 HLA 杂合性缺失 （LOH）、转录组抑制和选择性剪接的整体情况仍然具有挑战性。在最近的一项 Nature Genetics 研究中，Puttick 及其同事介绍了 MHC Hammer，这是一个强大的计算工具包，旨在剖析介导癌症免疫逃避的 HLA 破坏的复杂性。通过分析几个大型癌症队列的综合基因组和转录组数据，该研究强调了各种肿瘤类型中 HLA 破坏的普遍性，尤其是选择性剪接事件，并确定 HLA LOH 是肺腺癌转移过程中重要的免疫逃避机制。