Regional lymph node (LN) dissection is often used for the treatment of deep LNs in tumour surgery; however, the method is prone to incomplete LN dissection, trauma, complications, and other side effects. LN tracers make it easier to visualise and remove LNs. However, the current common LN tracers only have a single function or have radiation hazards related to their use. Therefore, the use of multi-functional LN tracers to improve the efficiency of deep LN eradication and reduce trauma and complications is currently a major challenge to be addressed. This study aimed to develop a multi-functional citrate-coated magnetite nanoparticle (CMNP) that could specifically drain to and accumulate in LNs. The CMNPs can be used as photoacoustic imaging contrast agents and magnetic resonance imaging contrast agents to image LNs. When an alternating magnetic field is applied, the CMNP can generate heat and raise the temperature of LNs, which is sufficient to coagulate and necrotise the LNs, thereby achieving LN inactivation. Eradication of LNs by magnetic hyperthermia is not limited by depth, and only LNs are specifically heated. Moreover, the method is less invasive and accurate for deep LNs.

中文翻译：

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磁性纳米颗粒介导的无创成像和淋巴结根除


区域淋巴结 （LN） 清扫术常用于治疗肿瘤手术中的深部 LNs;然而，该方法容易出现 LN 解剖不完全、创伤、并发症和其他副作用。LN 示踪剂使可视化和删除 LN 变得更加容易。然而，目前常见的 LN 示踪剂只有单一功能，或者存在与其使用相关的辐射危害。因此，使用多功能 LN 示踪剂来提高深度 LN 根除的效率并减少创伤和并发症是当前需要解决的重大挑战。本研究旨在开发一种多功能柠檬酸盐涂层的磁铁矿纳米颗粒 （CMNP），该颗粒可以特异性地排入 LN 并在 LN 中积累。CMNP 可用作光声成像造影剂和磁共振成像造影剂，以对 LN 进行成像。当施加交变磁场时，CMNP 可以产生热量并提高 LN 的温度，这足以使 LN 凝结和坏死，从而实现 LN 失活。磁热疗根除 LN 不受深度限制，只有 LN 被专门加热。此外，该方法对深度 LN 的侵入性较小且准确。