Diabetic osteoporosis (DOP) is an insidious complication of diabetes with limited therapeutic options. DOP is pathologically associated with various types of regulated cell death, but the precise role of ferroptosis in the process remains poorly understood. Asperosaponin VI (AVI), known for its clinical efficacy in treating bone fractures and osteoporosis, may exert its osteoprotective effects through mechanisms involving ferroptosis, however this has not been established.

中文翻译：

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Asperosaponin VI 抑制 DNMT 减轻 GPX4 抑制介导的成骨细胞铁死亡和糖尿病性骨质疏松症


糖尿病性骨质疏松症 （DOP） 是糖尿病的一种隐匿并发症，治疗选择有限。DOP 在病理学上与各种类型的调节细胞死亡相关，但铁死亡在此过程中的确切作用仍然知之甚少。Asperosaponin VI （AVI） 以其治疗骨折和骨质疏松症的临床疗效而闻名，可能通过涉及铁死亡的机制发挥其骨保护作用，但这尚未确定。