AimsUnderstanding the global burden of disease attributable to high body mass index (BMI) is essential for informing public health strategies and interventions to mitigate the impact of obesity‐related conditions.Methods and resultsThe global deaths and disability‐adjusted life years (DALYs) caused by high BMI were examined based on age, sex, year, and geographical location as well as socio‐demographic index. Globally in 2021, the deaths and DALYs attributable to high BMI have risen 2.54‐fold and 2.68‐fold for both sexes when compared to 1990. The number of global deaths linked to high BMI has risen for females from 828 147.16 (95% uncertainty interval [UI] 407 103.20–1 302 480.38) in 1990 to 2 013 089.03 (95% UI 979 000.37–3 076 044.71) in 2021, and for males from 631 386.07 (95% UI 315 452.97–988 213.75) in 1990 to 1 695 974.32 (95% UI 861 972.49–2 635 343.31) in 2021. The number of DALYs related to high BMI worldwide has risen for females from 26 097 463.34 (95% UI 11 042 501.33–42 206 794.07) in 1990 to 67 213 785.86 (95% UI 28 417 735.35–105 552 568.89) in 2021, and for males from 21 944 645.99 (95% UI 10 106 039.21–35 110 379.12) in 1990 to 61 306 297.23 (95% UI 27 566 755.49–94 931 874.52) in 2021. However, the age‐standardized rate of high‐BMI‐related deaths for females increased by 4.06% and 15.06% for males between 1990 and 2021, while the age‐standardized rate of high‐BMI‐related DALYs increased by 21.60% for females and 31.22% for males. Across the 21 Global Burden of Disease regions, in 2021, the highest age‐standardized rates of high‐BMI‐related deaths and DALYs were observed in Southern Sub‐Saharan Africa (125.12, 95% UI 71.21–183.13) and Oceania (3712.97, 95% UI 1666.49–5765.84), respectively.ConclusionEfforts to promote healthy weight management, lifestyle modifications, and early intervention for obesity‐related health complications are essential in reducing the morbidity and mortality associated with obesity and improving overall population health.

中文翻译：

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1990 年至 2021 年全球高体重指数导致全球疾病负担及到 2050 年的预测：2021 年全球疾病负担研究分析


目的了解高体重指数 （BMI） 引起的全球疾病负担对于为公共卫生策略和干预措施提供信息以减轻肥胖相关疾病的影响至关重要。方法和结果根据年龄、性别、年份和地理位置以及社会人口指数检查了由高 BMI 引起的全球死亡和残疾调整生命年 （DALY）。与 1990 年相比，2021 年全球高 BMI 导致的死亡人数和 DALY 分别增加了 2.54 倍和 2.68 倍。与高 BMI 相关的全球死亡人数从 1990 年的 828 147.16（95% 不确定性区间 [UI] 407 103.20–1 302 480.38）增加到 2021 年的 2 013 089.03（95% UI 979 000.37–3 076 044.71），男性从 1990 年的 631 386.07（95% UI 315 452.97–988 213.75）增加到 2021 年的 1 695 974.32（95% UI 861 972.49–2 635 343.31）。全球女性与高 BMI 相关的残疾调整生命年数量从 1990 年的 26 097 463.34（95% UI 11 042 501.33–42 206 794.07）增加到 2021 年的 67 213 785.86（95% UI 28 417 735.35–105 552 568.89），男性从 1990 年的 21 944 645.99（95% UI 10 106 039.21–35 110 379.12）增加到 2021 年的 61 306 297.23（95% UI 27 566 755.49–94 931 874.52）。然而，在 1990 年至 2021 年期间，女性高 BMI 相关死亡的年龄标准化率分别增加了 4.06% 和 15.06%，而女性高 BMI 相关 DALY 的年龄标化率分别增加了 21.60% 和男性 31.22%。在 2021 年全球疾病负担的 21 个区域中，撒哈拉以南非洲南部（125.12,95% UI 71.21-183.13）和大洋洲（3712.97,95% UI 1666.49-5765.84）的年龄标准化高 BMI 相关死亡率和 DALY 最高。结论努力促进健康的体重管理、生活方式的改变和对肥胖相关健康并发症的早期干预对于降低与肥胖相关的发病率和死亡率以及改善整体人口健康状况至关重要。