SummaryCellular membranes primarily consist of proteins and lipids. These proteins perform cellular functions such as metabolic regulation, environmental and hormonal signal sensing, and nutrient transport. There is increasing experimental evidence that certain lipids, particularly anionic phospholipids, can act as signaling molecules. Specific examples of functional regulation by anionic phospholipids in plant cells have been reported for transporters, channels, and even receptors. By regulating the structure and activity of membrane‐integral proteins, these phospholipids mediate the transport of phytohormones and ions, and elicit physiological responses to developmental and environmental cues. Phospholipids also control membrane protein abundance and lipid composition and abundance by facilitating vesicular trafficking. In this review, we discuss recent research that elucidates the mechanisms by which membrane‐integral transporters and channels are controlled via phospholipid signaling, as well as the regulation of membrane protein accumulation by phospholipids through coordinated removal, recycling, and degradation processes.

中文翻译：

---

植物细胞中阴离子磷脂介导的跨膜转运和细胞内膜运输


摘要细胞膜主要由蛋白质和脂质组成。这些蛋白质执行细胞功能，例如代谢调节、环境和激素信号感应以及营养物质运输。越来越多的实验证据表明，某些脂质，尤其是阴离子磷脂，可以充当信号分子。已经报道了植物细胞中阴离子磷脂对转运蛋白、通道甚至受体的功能调节的具体例子。通过调节膜整合蛋白的结构和活性，这些磷脂介导植物激素和离子的转运，并引发对发育和环境线索的生理反应。磷脂还通过促进囊泡运输来控制膜蛋白丰度和脂质组成和丰度。在这篇综述中，我们讨论了最近的研究，这些研究阐明了通过磷脂信号传导控制膜整合转运蛋白和通道的机制，以及磷脂通过协调去除、循环和降解过程对膜蛋白积累的调节。