Diabetes mellitus is a metabolic disorder that affects millions of individuals worldwide. Continuous glucose monitoring (CGM) offers a prevalent method for continuously monitoring interstitial glucose levels instead of traditional self-monitoring of blood glucose (BG), eliminating the need for finger pricking and providing only discrete data. However, challenges in accuracy persist in CGM, including substantial noise interference and tissue fluid erosion, as well as the pH fluctuations in the localized ISF microenvironment during acute inflammation periods. Herein, we reported a facile atmospheric plasma-induced grafting technique to surface functionalize a zwitterionic brush coating on the sensor, with the aim to adjust the sensor's microenvironmental chemistry. The zwitterionic brush-coated CGM (Z-coated CGM) could regulate pH values with a good glucose response in the pH range from 6.2 to 7.6 and a prolonged sensor life over the uncoated sensor. We evaluated the rat practice that the Z-coated CGM consistently outperformed the uncoated in tracking BG fluctuations, with higher correlation coefficients and significant noise reduction for both non-recalibration and recalibration. This technology holds substantial implications for subcutaneous embedded glucose monitors and facilitates CGMs in achieving independence from routine BG fingerstick calibrations.

中文翻译：

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调整连续血糖仪附近的局部微环境，以确保通过等离子体诱导接枝两性离子刷监测的准确性和寿命


糖尿病是一种影响全球数百万人的代谢紊乱。连续血糖监测 （CGM） 提供了一种持续监测间质血糖水平的流行方法，而不是传统的血糖 （BG） 自我监测，无需刺破手指，仅提供离散数据。然而，CGM 的准确性挑战仍然存在，包括大量的噪声干扰和组织液侵蚀，以及急性炎症期间局部 ISF 微环境中的 pH 值波动。在此，我们报道了一种简单的大气等离子体诱导接枝技术，使传感器上的两性离子刷涂层表面功能化，目的是调整传感器的微环境化学。两性离子刷涂 CGM（Z 涂层 CGM）可以调节 pH 值，在 pH 值 6.2 至 7.6 范围内具有良好的葡萄糖响应，并且比未涂覆的传感器延长传感器寿命。我们评估了大鼠的做法，即 Z 涂层 CGM 在跟踪 BG 波动方面始终优于未涂层，非重新校准和重新校准均具有更高的相关系数和显着的降噪。这项技术对皮下嵌入式血糖监测仪具有重大意义，并有助于 CGM 实现独立于常规 BG 指尖校准。