Nanomedicines, by significantly enhancing the solubility, stability, and targeted delivery of therapeutic agents, have emerged as transformative tools in light-induced therapies, particularly in the context of oncology. These advancements are attributed to their ability to mediate autophagy through light activation, thereby revolutionizing cancer treatment paradigms. This review provides a comprehensive analysis of the state-of-the-art integration of nanomedicines with phototherapy techniques, emphasizing their role in modulating autophagy within cancer cells. It delineates the potential of light-responsive nanomaterials to induce selective tumor cell death by precisely regulating over-activated autophagy pathways. Additionally, it discusses innovative strategies for combining nanomedicines with phototherapy and other clinical modalities for tumor treatment, as well as integrating autophagy with various forms of programmed cell death to address challenges related to drug resistance and therapeutic efficacy. By synthesizing recent advancements and delineating future research directions, this review offers a thorough perspective on the optimization of light-induced autophagy through nanomedicines, highlighting novel strategies for enhancing cancer treatment efficacy.

中文翻译：

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纳米药物和光疗的创新整合以调节自噬以增强肿瘤根除


纳米药物通过显著提高治疗剂的溶解度、稳定性和靶向递送，已成为光诱导疗法的变革性工具，尤其是在肿瘤学的背景下。这些进步归因于它们通过光激活介导自噬的能力，从而彻底改变癌症治疗范式。这篇综述全面分析了纳米药物与光疗技术的最新整合，强调了它们在调节癌细胞内自噬中的作用。它描述了光响应纳米材料通过精确调节过度激活的自噬途径诱导选择性肿瘤细胞死亡的潜力。此外，它还讨论了将纳米药物与光疗和其他临床方式相结合进行肿瘤治疗的创新策略，以及将自噬与各种形式的程序性细胞死亡相结合，以应对与耐药性和治疗效果相关的挑战。通过综合最新进展和描绘未来的研究方向，本文为通过纳米药物优化光诱导自噬提供了全面的视角，强调了提高癌症治疗效果的新策略。