Postural Orthostatic Tachycardia Syndrome (POTS) is a chronic autonomic condition hallmarked by orthostatic intolerance and tachycardia in the upright position. POTS impacts approximately 1–3 million people in the U.S. alone, in which the majority of patients are premenopausal women. The etiology of POTS is multi-factorial with three primary clinical subtypes, including neuropathic, hyperadrenergic, and hypovolemic POTS. Recent evidence suggests potential metabolic associations with POTS pathophysiology, particularly involving insulin resistance and abnormal vasoactive gut hormones. This review aims to characterize POTS phenotypes and explore potential metabolic links, focusing on insulin resistance and vasoactive gut hormones. Understanding the metabolic aspects of POTS pathophysiology could provide novel insights into its mechanisms and guide therapeutic approaches.

中文翻译：

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体位性直立性心动过速综合征的代谢靶标：简短的主题综述


体位性直立性心动过速综合征 （POTS） 是一种慢性自主神经疾病，其特征是直立不耐受和直立位心动过速。仅在美国，POTS 就影响了大约 1-300 万人，其中大多数患者是绝经前妇女。POTS 的病因是多因素的，有三种主要的临床亚型，包括神经性、肾上腺素能亢进性和低血容量性 POTS。最近的证据表明，POTS 病理生理学存在潜在的代谢关联，特别是涉及胰岛素抵抗和异常的血管活性肠道激素。本综述旨在表征 POTS 表型并探索潜在的代谢联系，重点关注胰岛素抵抗和血管活性肠道激素。了解 POTS 病理生理学的代谢方面可以为其机制提供新的见解并指导治疗方法。