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Minor trauma and venous thromboembolism: the threshold for antithrombotic prophylaxis.
Haematologica ( IF 8.2 ) Pub Date : 2024-12-01 , DOI: 10.3324/haematol.2023.284612 Alexandre Tran,Pamela L Lutsey,Marc Carrier
Haematologica ( IF 8.2 ) Pub Date : 2024-12-01 , DOI: 10.3324/haematol.2023.284612 Alexandre Tran,Pamela L Lutsey,Marc Carrier
Trauma is an established risk factor for venous thromboembolism (VTE). Whether minor trauma is linked to greater risk of VTE remains unclear given that many studies evaluating trauma and VTE risk have not differentiated risk by trauma severity. Furthermore, the underlying risk of VTE is not uniform across all injured patients. While it is generally accepted that severely and moderately injured patients requiring prolonged hospitalization benefit from early and consistent administration of thromboprophylaxis, the threshold for its initiation following minor injury or in patients managed in an ambulatory setting is less clear. This review will describe how trauma is classified, summarize the evidence of the risk of VTE in patients with minor trauma, and guide clinicians through an approach to individualize these treatment decisions based on contemporary evidence. Guidance will be provided for both injured patients requiring hospitalization (who may have severe, moderate or minor trauma), and those suitable to be managed in an ambulatory setting (minor trauma).
中文翻译:
轻微外伤和静脉血栓栓塞:抗血栓预防的阈值。
外伤是静脉血栓栓塞 (VTE) 的既定危险因素。鉴于许多评估创伤和 VTE 风险的研究并未根据创伤严重程度区分风险,轻微创伤是否与 VTE 风险增加有关仍不清楚。此外,所有受伤患者发生 VTE 的潜在风险并不相同。虽然人们普遍认为需要长期住院治疗的重度和中度损伤患者受益于早期和持续的血栓预防治疗,但在轻伤后或在门诊接受治疗的患者中开始治疗的阈值尚不清楚。本综述将描述如何对创伤进行分类,总结轻微创伤患者发生 VTE 风险的证据,并指导临床医生根据当代证据制定个体化这些治疗决策。将为需要住院治疗的受伤患者(可能有严重、中度或轻微创伤)和适合在门诊环境中治疗的患者(轻微创伤)提供指导。
更新日期:2024-12-01
中文翻译:
轻微外伤和静脉血栓栓塞:抗血栓预防的阈值。
外伤是静脉血栓栓塞 (VTE) 的既定危险因素。鉴于许多评估创伤和 VTE 风险的研究并未根据创伤严重程度区分风险,轻微创伤是否与 VTE 风险增加有关仍不清楚。此外,所有受伤患者发生 VTE 的潜在风险并不相同。虽然人们普遍认为需要长期住院治疗的重度和中度损伤患者受益于早期和持续的血栓预防治疗,但在轻伤后或在门诊接受治疗的患者中开始治疗的阈值尚不清楚。本综述将描述如何对创伤进行分类,总结轻微创伤患者发生 VTE 风险的证据,并指导临床医生根据当代证据制定个体化这些治疗决策。将为需要住院治疗的受伤患者(可能有严重、中度或轻微创伤)和适合在门诊环境中治疗的患者(轻微创伤)提供指导。