Prevalence and incidence of HIV among people aged 50 years and older continue to rise worldwide, generating increasing awareness among care providers, scientists, and the HIV community about the importance of brain health in older adults with HIV. Many age-related factors that adversely affect brain health can occur earlier and more often among people with HIV, including epigenetic ageing, chronic medical conditions (eg, cardiovascular disease), and age-related syndromes (eg, frailty). Extensive dialogue between HIV community leaders, health-care providers, and scientists has led to the development of a multidimensional response strategy to protect and enhance brain health in people ageing with HIV that spans across public health, clinical spaces, and research spaces. This response strategy was informed by integrated ageing care frameworks and is centred on prevention, early detection, and management of brain health issues associated with HIV (eg, neurocognitive disorders), with specific considerations for low-resource or middle-resource countries. A collaborative, international, and data-informed update of the diagnostic criteria for HIV-associated neurocognitive disorders is a cornerstone of the proposed response strategy. The proposed response strategy includes a dynamic, international, online knowledge hub that will provide a crucial community resource for emerging evidence on the brain health of people ageing with HIV.

中文翻译：

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促进 HIV 感染者的健康认知老龄化。


全球 50 岁及以上人群的 HIV 患病率和发病率持续上升，使护理提供者、科学家和 HIV 社区越来越意识到 HIV 感染老年人大脑健康的重要性。许多对大脑健康产生不利影响的年龄相关因素在 HIV 感染者中可能更早、更频繁地发生，包括表观遗传衰老、慢性疾病（如心血管疾病）和年龄相关综合征（如虚弱）。HIV 社区领袖、医疗保健提供者和科学家之间的广泛对话促成了多维应对策略的制定，以保护和增强 HIV 感染者的大脑健康，该策略跨越公共卫生、临床空间和研究空间。该应对策略以综合老龄化护理框架为依据，以预防、早期发现和管理与 HIV 相关的脑健康问题（例如，神经认知障碍）为中心，并特别考虑资源匮乏或中等资源的国家。对 HIV 相关神经认知障碍的诊断标准进行协作、国际和数据知情的更新是拟议应对策略的基石。拟议的应对策略包括一个充满活力的国际在线知识中心，该中心将为 HIV 感染者大脑健康的新证据提供重要的社区资源。