Herein, visible-light-driven radical–radical cross-coupling for the construction of a C(sp³)–S bond to afford various cyanoalkyl thioethers through EDA complex-promoted C–C and C–H bond cleavage is described. The photoactivation of a transiently assembled chromophore between thiolate anions and cycloketone oxime esters is critical to the generation of the C(sp³)–S bond. Notably, we also realize the in situ formed EDA complex-mediated 1,3-hydrogen atom transfer (HAT) to construct diverse thioethers under the standard conditions. This synthetic method features easily available substrates, a wide substrate scope, and mild reaction conditions, and has potential to be used for the preparation of valuable sulfides.

中文翻译：

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可见光诱导的自由基 C（sp3）-S 偶联物联用于合成氰烷基硫醚


在此，描述了可见光驱动的自由基-自由基交叉偶联，用于构建 C（sp³）-S 键，以通过 EDA 复合物促进的 C-C 和 C-H 键裂解得到各种氰基烷基硫醚。硫代阴离子和环酮肟酯之间瞬时组装的发色团的光活化对于 C（sp³）-S 键的产生至关重要。值得注意的是，我们还实现了原位形成的 EDA 复合物介导的 1,3-氢原子转移 （HAT），以在标准条件下构建多种硫醚。这种合成方法具有易于获得的底物、广泛的底物范围和温和的反应条件，并有可能用于制备有价值的硫化物。