Cell fate determination and transition are of paramount importance in biology and medicine. Naive pluripotency could be achieved by reprogramming differentiated cells. However, the mechanism is less clear. Osmolarity is an essential physical factor that acts on living cells, especially for pluripotent cells, but its significance in cell fate transition remains unexplored.

中文翻译：

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低渗透压通过重塑细胞骨架和增加染色质的可及性来促进幼稚多能性


细胞命运的确定和转换在生物学和医学中至关重要。可以通过重编程分化细胞来实现幼稚多能性。然而，机制尚不清楚。渗透压是作用于活细胞的重要物理因素，尤其是对于多能细胞，但其在细胞命运转变中的重要性仍未得到探索。