Asthma is a chronic inflammatory disease that arises due to an exacerbated immune response causing narrowing and hypersensitivity of the airways [1]. The full aetiology of asthma is not fully understood; however, several studies have shown the role of genetic, immunological and environmental factors in its development or severity. Asthma remains a significant health challenge, contributing to substantial morbidity and, in some instances, mortality. Therefore, it is crucial to enhance our understanding of this condition and to identify new biomarkers. From an immunological point of view, different cell types, such as T-cells, mast cells and eosinophils, play a crucial role in disease induction or exacerbation [2]. T-cells, in particular Th2 and Th17 cells, have been shown to be involved in promoting asthma severity by promoting the recruitment of immune cells, such as eosinophils and neutrophils, respectively [3, 4].

哮喘是一种慢性炎症性疾病，是由于免疫反应加剧导致气道狭窄和过敏而引起的 [1]。哮喘的完整病因尚不完全清楚;然而，一些研究表明遗传、免疫和环境因素在其发展或严重程度中的作用。哮喘仍然是一项重大的健康挑战，导致大量发病率，在某些情况下还会导致死亡率。因此，增强我们对这种情况的理解并确定新的生物标志物至关重要。从免疫学的角度来看，不同的细胞类型，如 T 细胞、肥大细胞和嗜酸性粒细胞，在疾病诱导或恶化中起着至关重要的作用 [2]。T 细胞，特别是 Th2 和 Th17 细胞，已被证明通过促进免疫细胞（如嗜酸性粒细胞和中性粒细胞）的募集来促进哮喘的严重程度 [3， 4]。