Existing functional genomics datasets are European-centric. The Asian Immune Diversity Atlas incorporated single-cell RNA-sequencing data from approximately 1 million peripheral blood mononuclear cells from around 500 donors of diverse Asian ancestries. Mapping of splicing quantitative trait loci revealed context-specific regulation of alternative splicing, as well as cell-type and ancestry-specific genetic effects on complex diseases.

中文翻译：

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来自不同亚洲供体的血细胞类型选择性剪接的遗传控制


现有的功能基因组学数据集以欧洲为中心。亚洲免疫多样性图谱整合了来自约 500 名不同亚洲血统的供体的大约 100 万个外周血单核细胞的单细胞 RNA 测序数据。剪接数量性状位点的定位揭示了选择性剪接的上下文特异性调控，以及细胞类型和祖先特异性遗传对复杂疾病的影响。