The nervous and immune systems are closely interconnected, and influence the onset and progress of various diseases. Accordingly, understanding the interaction of the neural system and the immune system becomes very important for the treatment of intractable diseases with the analysis of therapeutic mechanisms, such as autoimmune diseases, neurodegenerative diseases, cancers, and so on. The conventional immunomodulation treatments have been mainly carried out by drug administration, but they have suffered from systemic negative side-effects with only limited effects on the specific disease. In this Perspective, photonic nanomaterials and devices are reviewed and discussed for digitally controlled neurostimulating photomedicine via photobiomodulation and optogenetics from the unique viewpoint of neuro-immune cross-talks. The prospects and perspectives to integrate photonic nanomaterials with advanced wearable and implantable healthcare devices are also provided and highlighted to revolutionize the therapeutic strategies by the interaction of neural and immune systems, and optimize the treatment protocols for futuristic digital photomedicine. This approach will revolutionize the fields of neurostimulation and immune regulation for further clinical applications.

中文翻译：

---

基于神经免疫串扰的多功能光子纳米材料及数字光医学器件


神经和免疫系统密切相关，并影响各种疾病的发生和发展。因此，了解神经系统和免疫系统的相互作用对于治疗难治性疾病（如自身免疫性疾病、神经退行性疾病、癌症等）的治疗变得非常重要。传统的免疫调节治疗主要通过给药进行，但它们遭受了全身性的负面副作用，对特定疾病的影响有限。在这个观点中，从神经免疫串扰的独特角度，回顾和讨论了通过光生物调节和光遗传学进行数字控制神经刺激光医学的光子纳米材料和器件。还提供并强调了将光子纳米材料与先进的可穿戴和植入式医疗保健设备相结合的前景和前景，以通过神经和免疫系统的相互作用彻底改变治疗策略，并优化未来数字光医学的治疗方案。这种方法将彻底改变神经刺激和免疫调节领域，用于进一步的临床应用。