Cancer metastasis remains a critical factor contributing to the current limitations in cancer treatment. Photothermal immunotherapy has emerged as a safe and potent therapeutic approach, demonstrating the capability to suppress tumor growth and metastasis. While researchers have extensively investigated various structural modifications to enhance photothermal conversion performance, the influence of molecular configuration has received comparatively limited attention. In this study, we synthesized two isomers, CZTBT and LVTBT, which possessed distinct configurations. LVTBT, characterized by a flatter molecular configuration, exhibited an extended absorption wavelength and a higher molar extinction coefficient. Its excited state facilitated stronger rotation for non-radiative transitions, leading to a high photothermal conversion efficiency (PCE) of 36.3%. When combined with R848, LVTBT@R848 nanoparticles (NPs)-mediated photothermal immunotherapy functioned as an in situ tumor vaccine, promoting the maturation of dendritic cells (DCs), T cell infiltration, and the differentiation of natural killer (NK) cells and memory T cells, thereby activating the strong immune response. Consequently, it significantly inhibited the growth of both primary and distant tumors, while also limiting lung metastasis. In summary, this study proposed a configuration-mediated non-radiative transition strategy for efficient photothermal immunotherapy, advancing the frontiers of organic photothermal agents (OPTAs) design and synthesis.

中文翻译：

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R848 辅助光热免疫疗法通过原位肿瘤疫苗策略抑制肿瘤生长和转移的配置介导的有效非辐射转变


癌症转移仍然是导致当前癌症治疗局限性的关键因素。光热免疫疗法已成为一种安全有效的治疗方法，证明了抑制肿瘤生长和转移的能力。虽然研究人员已经广泛研究了各种结构修饰以提高光热转换性能，但分子构型的影响受到的关注相对有限。在这项研究中，我们合成了两种异构体 CZTBT 和 LVTBT，它们具有不同的构型。LVTBT 的特点是分子构型更平坦，表现出扩展的吸收波长和更高的摩尔消光系数。其激发态促进了非辐射跃迁的更强旋转，从而实现了 36.3% 的高光热转换效率 （PCE）。当与 R848 联合使用时，LVTBT@R848纳米颗粒 （NPs） 介导的光热免疫疗法起原位肿瘤疫苗的作用，促进树突状细胞 （DC） 的成熟、T 细胞浸润以及自然杀伤 （NK） 细胞和记忆 T 细胞的分化，从而激活强烈的免疫反应。因此，它显着抑制了原发性和远处肿瘤的生长，同时也限制了肺转移。综上所述，本研究提出了一种构型介导的非辐射过渡策略，用于高效的光热免疫治疗，推进了有机光热剂 （OPTAs） 设计和合成的前沿。