Building functional fluorophores from a simple scaffold. In their Research Article (e202415627), Lei Zhang, Su Jing, Thorben Cordes, and co-workers use the Ugi-4-component reaction to assemble fluorogenic dye molecules that selectively localize to mitochondria or lysosomes. The multifunctional fluorophores are not only fluorogenic but also induce pyroptosis in living cancer cells. The study shows the potential of scaffold-based synthesis for creation of new functional fluorophores.

中文翻译：

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封面：用于靶向细胞成像和焦亡的多功能荧光团的模块化设计和支架合成


从简单的支架构建功能性荧光团。在他们的研究文章 （e202415627） 中，Lei Zhang、Su Jing、Thorben Cordes 及其同事使用 Ugi-4 组分反应组装选择性定位于线粒体或溶酶体的荧光染料分子。多功能荧光团不仅具有荧光性，而且可在活癌细胞中诱导焦亡。该研究表明了基于支架的合成在创建新的功能性荧光团方面的潜力。