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Arterial calcification in the heart–brain axis and cognitive performance over time
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2024-12-03 , DOI: 10.1002/alz.14374
Anna M. Streiber, Tim C. van den Beukel, Ilse vom Hofe, Julia Neitzel, Meike W. Vernooij, Daniel Bos, Elisabeth J. Vinke

BACKGROUNDWhile cross‐sectional studies suggest a link between arteriosclerosis and cognition, longitudinal research is lacking. We investigated how arteriosclerosis in the heart–brain axis is related to cognitive performance trajectories over time.METHODSWithin the population‐based Rotterdam Study, 2368 participants underwent noncontrast CT to quantify arterial calcification, a hallmark of arteriosclerosis, in five major arteries in the heart–brain axis. Following this scan, participants underwent repeated cognitive testing. The association between baseline calcification and longitudinal cognitive test performance was investigated using mixed models.RESULTSHigher calcification was associated with worse baseline cognitive performance across domains (e.g., β for global cognition per 10‐percentile increase of intracranial carotid artery calcification: −0.01 [95% confidence interval (CI): −0.03, −0.00]). Cognition declined faster across all cognitive tests, specifically for the intracranial carotid artery (p ≤ 0.001).DISCUSSIONArterial calcification is associated with accelerated cognitive decline across domains, especially for arteries closer to the brain. This effect may be attributable to hemodynamic changes preceding neurovascular damage.Highlights Arterial calcification is related to accelerated cognitive decline. Arterial calcification closer to the brain exerts the most influence on cognitive decline. Vascular damage influences cognitive decline across various domains.

中文翻译:


心脑轴动脉钙化和认知能力随时间的变化



背景尽管横断面研究表明动脉硬化与认知之间存在联系,但缺乏纵向研究。我们研究了心脑轴动脉硬化如何与认知表现轨迹随时间的关系。方法在基于人群的鹿特丹研究中,2368 名参与者接受了非增强 CT 以量化心脑轴五条主要动脉的动脉钙化,这是动脉硬化的标志。扫描后,参与者接受了重复的认知测试。使用混合模型研究基线钙化与纵向认知测试表现之间的关联。结果高钙化与跨领域较差的基线认知表现相关(例如,颅内颈动脉钙化每增加 10 个百分位,整体认知β:-0.01 [95% 置信区间 (CI):-0.03,-0.00])。在所有认知测试中,认知能力下降得更快,特别是颅内颈动脉 (p ≤ 0.001)。讨论骨钙化与跨领域的认知能力加速下降有关,尤其是对于更靠近大脑的动脉。这种影响可能归因于神经血管损伤之前的血流动力学变化。亮点 动脉钙化与认知能力加速下降有关。靠近大脑的动脉钙化对认知能力下降的影响最大。血管损伤会影响各个领域的认知能力下降。
更新日期:2024-12-03
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