Literature indicates a potential association between dairy consumption and risk of Parkinson´s disease (PD), especially among men, yet the results remain inconclusive. We investigated this association in a large prospective European cohort. Dietary and non-dietary data was collected from 183,225 participants of the EPIC-for-Neurodegenerative-Diseases (EPIC4ND) cohort, a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Crude and multivariable-adjusted Cox proportional hazards models were employed to examine potential associations between baseline dietary intake of dairy, calcium and vitamin D with incident PD risk. No relationship was observed between dairy consumption (HR 1.07, 95% CI 0.82–1.39), individual dairy products (milk: HR 0.95, 95% CI 0.73–1.23; yogurt: HR 1.03, 95% CI 0.82–1.29; cheese: HR 1.13, 95% CI 0.85–1.51), or vitamin D (HR 1.08, 95% CI 0.80–1.45) with PD risk. However, we observed a risk-increasing association with higher calcium intakes (HR 1.33, 95% CI 1.00-1.78, p for trend = 0.031), which was more pronounced in men (HR 1.50, 95% CI 1.00-2.25, p for trend = 0.044) and in ever smokers (HR 1.64, 95% CI 1.06–2.53, p for trend = 0.014). No compelling evidence was found for an association between dairy products or vitamin D intake and PD risk indicating a potentially limited relevance of dairy intake in PD risk than previously described. Our observations of a positive association between dietary calcium intake and PD risk in men and in ever smokers require further validation.

文献表明乳制品消费与帕金森病 （PD） 风险之间存在潜在关联，尤其是在男性中，但结果仍无定论。我们在一个大型前瞻性欧洲队列中调查了这种关联。饮食和非饮食数据是从 EPIC 治疗神经退行性疾病 （EPIC4ND） 队列的 183,225 名参与者那里收集的，该队列是欧洲癌症和营养前瞻性调查 （EPIC） 队列的一个子队列。采用粗略和多变量调整的 Cox 比例风险模型来检查乳制品、钙和维生素 D 的基线膳食摄入量与发生 PD 风险之间的潜在关联。未观察到乳制品消费（HR 1.07,95% CI 0.82-1.39）、单个乳制品（牛奶：HR 0.95,95% CI 0.73-1.23;酸奶：HR 1.03,95% CI 0.82-1.29;奶酪：HR 1.13,95% CI 0.85-1.51）或维生素 D （HR 1.08,95% CI 0.80-1.45）与 PD 风险之间的关系。然而，我们观察到与较高的钙摄入量 （HR 1.33,95% CI 1.00-1.78，趋势 p = 0.031） 的风险增加相关，这在男性 （HR 1.50,95% CI 1.00-2.25，趋势 = 0.044） 和曾经吸烟者 （HR 1.64,95% CI 1.06-2.53，趋势 p = 0.014） 中更为明显。没有发现令人信服的证据表明乳制品或维生素 D 摄入量与 PD 风险之间存在关联，表明乳制品摄入量与 PD 风险的相关性可能比以前描述的要有限。我们对男性和曾经吸烟者的膳食钙摄入量与 PD 风险呈正相关的观察需要进一步验证。