The SCHEMATIC resource combines CRISPR pairwise gene knockout experiments across tumor cell types with large-scale drug sensitivity assays to identify a core network of highly penetrant, synthetic lethal genetic interactions that can help to match individuals with cancer to targeted therapies.

中文翻译：

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为精准肿瘤学发现合成致死基因相互作用的蓝图


SCHEMATIC 资源将跨肿瘤细胞类型的 CRISPR 成对基因敲除实验与大规模药物敏感性测定相结合，以确定高度渗透、合成致命遗传相互作用的核心网络，这有助于将癌症个体与靶向治疗相匹配。