Pelvic floor disorders (PFD) are common among women, causing dysfunction, incontinence, and discomfort. Surgeries to repair the descended tissues can result in complications due to implant material design, particularly from the hardness and mechanical mismatch to native tissue. A more flexible implant could reduce complications, such as exposure and tissue erosion. This work seeks to characterize a 3D-printed double-crosslinked hydrogel tissue scaffold consisting primarily of polyvinyl alcohol (PVA). It also compares its static/dynamic/thermal/biological properties to existing commercial products used in PFD therapies, showing our pelvic mesh's biodegradability/robustness advantages over the commercial ones. Tensile tests revealed that the hydrogel scaffold was more compliant than the commercial alternatives. Dynamic mechanical testing has shown that these polymers are durable enough to support organs with specific weight above the pelvic floor. In vivo mouse studies demonstrated low inflammation and good biocompatibility over a 28-day period. The development of this scaffold offers a promising alternative for more effective, long-lasting PFD treatments with fewer post-operative complications, advancing personalized medicine.

中文翻译：

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3D 可打印生物聚合物作为骨盆底支架


盆底疾病 （PFD） 在女性中很常见，会导致功能障碍、失禁和不适。由于植入物材料的设计，修复下行组织的手术可能会导致并发症，特别是与天然组织的硬度和机械不匹配。更灵活的植入物可以减少并发症，例如暴露和组织侵蚀。这项工作旨在表征主要由聚乙烯醇 （PVA） 组成的 3D 打印双交联水凝胶组织支架。它还将其静态/动力学/热/生物特性与 PFD 疗法中使用的现有商业产品进行了比较，展示了我们的盆腔网片相对于商业产品的生物降解性/稳健性优势。拉伸测试表明，水凝胶支架比商业替代品更顺应。动态力学测试表明，这些聚合物足够耐用，可以支撑骨盆底以上具有比重的器官。体内小鼠研究表明，在 28 天内具有低炎症和良好的生物相容性。这种支架的开发为更有效、更持久的 PFD 治疗提供了一种有前途的替代方案，术后并发症更少，推进了个性化医疗。