Depression and cardiovascular diseases are two of the world's major health problems. Escitalopram (ESC) is widely used because of its safety in relation to other drugs in that class; however, it can affect the cardiovascular system. The present study evaluated the cardiovascular parameters of depressive-like male rats and the cardiovascular effects of ESC treatment on that condition. The EMS protocol consisted of separating the litter from the dam for 3 h over 13 days. Animals were anesthetized with tribromoethanol (250 mg/kg, intraperitoneally) and the catheters were inserted into the femoral and into the femoral vein. Depressive-like rats showed an increase in the pressor response to phenylephrine (Emax:depressive = 50.36 ± 2.997 mmHg; non-depressive = 39.51 ± 3.328 mmHg; p < 0.05) and a reduction in the EC50 (depressive = 0.6203 ± 0.03005 μg/kg; non-depressive = 0.7320 ± 0.03519 μg/kg; p < 0.05) with no change in the other cardiovascular parameters. After treatment with ESC, a reduction of intrinsic heart rate was observed in the depressive-like rats (control: 342 ± 6 bpm; ESC: 316 ± 5 bpm; p < 0.05). In addition, ESC treatment increased the bradycardic (control: −97.81 ± 8.3 bpm; ESC: −137.1 ± 12.31 bpm; p = 0.0236; t = 2.502) during the baroreflex response, caused by an increase in cardiac parasympathetic modulation in the heart, in depressive-like rats (p < 0.001). The findings suggest that depressive-like rats showed cardiovascular changes, and that ESC treatment was able to reverse these changes, suggesting that ESC has a good safety profile for depressive patients with cardiovascular disease due to increased parasympathetic modulation.

中文翻译：

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早期母体分离和艾司西酞普兰治疗对抑郁样行为大鼠的心血管影响


抑郁症和心血管疾病是世界上两个主要的健康问题。艾司西酞普兰 （ESC） 被广泛使用，因为它相对于该类别的其他药物而言具有安全性;但是，它会影响心血管系统。本研究评估了抑郁样雄性大鼠的心血管参数以及 ESC 治疗对该病症的心血管影响。EMS 方案包括在 13 天内将垫料与母体分离 3 小时。用三溴乙醇 （250 mg/kg，腹膜内） 麻醉动物，并将导管插入股骨和股静脉。抑郁样大鼠对去氧肾上腺素的升压反应增加 （Emax：抑郁 = 50.36 ± 2.997 mmHg;非抑郁 = 39.51 ± 3.328 mmHg;p < 0.05）和 EC50 降低 （抑郁 = 0.6203 ± 0.03005 μg/kg;非抑郁 = 0.7320 ± 0.03519 μg/kg;p < 0.05），其他心血管参数没有变化。用 ESC 处理后，在抑郁样大鼠中观察到内在心率降低 （对照组：342 ± 6 bpm;ESC：316 ± 5 bpm;p < 0.05）。此外，ESC 治疗增加了心动过缓 （对照： -97.81 ± 8.3 bpm;ESC：-137.1 ± 12.31 bpm;p = 0.0236;t = 2.502） 在压力反射反应期间，由心脏中心脏副交感神经调节的增加引起，在抑郁样大鼠 （p < 0.001） 中。研究结果表明，抑郁样大鼠表现出心血管变化，并且 ESC 治疗能够逆转这些变化，这表明由于副交感神经调节增加，ESC 对患有心血管疾病的抑郁症患者具有良好的安全性。