Intermolecular regioselective C–C and C–O bond cleavage and amination were accomplished using a CuCl₂–TBN system under mild reaction conditions. This protocol represents a simple, efficient and highly functional group compatible method for the synthesis of unsymmetrically substituted N-aryl oxalamides. The present reaction opens an alternative path using H₂O as the source of oxygen for the preparation of N-aryl oxalamides via regioselective C–C and C–O bond cleavage and the formation of two new C–N bonds.

中文翻译：

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TBN 促进的区域选择性 C-C 键裂解：合成不对称取代的 N-芳基草酸酰胺的新策略


分子间区域选择性 C-C 和 C-O 键裂解和胺化是在温和的反应条件下使用 CuCl_2-TBN 系统完成的。该方案代表了一种简单、高效且高度官能团兼容的组兼容方法，用于合成不对称取代的 N-芳基草酰酰胺。本反应开辟了一条替代途径，使用 H₂O 作为氧源，通过区域选择性 C-C 和 C-O 键裂解和形成两个新的 C-N 键来制备 N-芳基草胺。