Although the chiral recognition ability of nanomaterials is known to play a crucial role in the chiral discrimination of enantiomers, it remains challenging to precisely regulate the chiral recognition ability predictably and on demand. In this work, a regulable chiral recognition platform is designed based on the photothermal effect of popcorn-like gold nanoparticles (AuNPs)/bovine serum albumin (BSA). First, AuNPs with excellent chiral recognition ability are prepared for the discrimination of tyrosine (Tyr) enantiomers. Subsequently, AuNPs can be combined with BSA through the Au–S bond. The obtained AuNPs/BSA exhibits the opposite chiral recognition ability to AuNPs due to the inherent chirality of BSA. Interestingly, BSA can also be destroyed relying on the photothermal effect of AuNPs and the excitation of near-infrared (NIR) light. Therefore, the resulting AuNPs/BSA/NIR reversibly displays the same chiral recognition ability as AuNPs. A regulable chiral recognition platform is constructed for chiral discrimination of Tyr enantiomers, which can satisfy the purpose of predictable and on-demand regulation of the recognition ability of nanomaterials and might be a potential candidate for detection and therapy in vivo.

中文翻译：

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基于爆米花样金纳米颗粒/牛血清白蛋白光热效应的可调节手性识别平台的构建


尽管已知纳米材料的手性识别能力在对映异构体的手性区分中起着至关重要的作用，但要可预测地按需精确调节手性识别能力仍然具有挑战性。在这项工作中，基于爆米花样金纳米颗粒 （AuNPs）/牛血清白蛋白 （BSA） 的光热效应设计了一个可调节的手性识别平台。首先，制备了具有优异手性识别能力的 AuNPs 用于区分酪氨酸 （Tyr） 对映异构体。随后，AuNPs 可以通过 Au-S 键与 BSA 结合。由于 BSA 固有的手性，获得的 AuNPs/BSA 表现出与 AuNPs 相反的手性识别能力。有趣的是，BSA 也可以依靠 AuNP 的光热效应和近红外 （NIR） 光的激发而被破坏。因此，所得的 AuN/BSA/NIR 可逆地显示出与 AuNPs 相同的手性识别能力。构建了用于 Tyr 对映异构体手性鉴别的可控手性识别平台，可以满足对纳米材料识别能力的可预测和按需调控目的，可能成为体内检测和治疗的潜在候选者。