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Kidney Insights: Harnessing Evolution and Biomimetics to Enhance Planetary Health.
Journal of the American Society of Nephrology ( IF 10.3 ) Pub Date : 2024-11-22 , DOI: 10.1681/asn.0000000582
Peter Stenvinkel,Paul G Shiels,Peter Kotanko,Pieter Evenepoel,Richard J Johnson

Planetary health encompasses the understanding that the long-term well-being of humanity is intrinsically linked to the health of global ecological systems. Unfortunately, current practices often overlook this principle, leading to a human-oriented (anthropocentric) worldview that has resulted in heightened greenhouse gas emissions, increased heat stress, lack of access to clean water and pollution, threatening both the environment and the health and survival of Homo sapiens and countless other species. One significant consequence of these environmental changes is the exacerbation of inflammatory and oxidative stressors, which not only contributes to common lifestyle diseases, but also accelerate the aging process. We advocate for a shift away from our current anthropocentric frameworks to an approach that focuses on nature's solutions that developed from natural selection over the eons. This approach, which encompasses the field of biomimicry, may provide insights that can help protect against an 'inflammatory phenotype' to mitigate physiological and cellular senescence and provide a buffer against environmental stressors. Gaining insights from how animals have developed ingenious approaches to combat adversity through the evolutionary process of natural selection not only provide solutions for climate change, but also confronts the rising burden of lifestyle diseases that accumulate with age.

中文翻译:


肾脏洞察:利用进化和仿生学来增强地球健康。



地球健康包括这样一种理解,即人类的长期福祉与全球生态系统的健康有着内在的联系。不幸的是,目前的做法往往忽视了这一原则,导致了一种以人为本(以人类为中心)的世界观,这导致了温室气体排放的增加、热应激的增加、缺乏清洁水和污染,威胁到环境以及智人和无数其他物种的健康和生存。这些环境变化的一个重要后果是炎症和氧化应激源的加剧,这不仅会导致常见的生活方式疾病,还会加速衰老过程。我们倡导从目前的人类中心主义框架转变为一种专注于自然解决方案的方法,这些解决方案是从亿万年来的自然选择中发展而来的。这种方法涵盖了仿生学领域,可能提供有助于防止“炎症表型”的见解,以减轻生理和细胞衰老,并为环境压力源提供缓冲。从动物如何通过自然选择的进化过程开发出巧妙的方法来对抗逆境中获得见解,不仅可以为气候变化提供解决方案,还可以应对随着年龄增长而积累的日益严重的生活方式疾病负担。
更新日期:2024-11-22
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