It is interesting to find pathologically that leukocytes, especially neutrophils, tend to adhere in the liver sinusoids dominantly but not in the postsinusoidal venules. While both views of receptor-ligand interactions and physical trapping are proposed for mediating leukocyte adhesion in liver sinusoids, integrated investigations for classifying their respective contributions are poorly presented. With a combination of Monte Carlo simulation and immersed boundary method, this study explored numerically the effects of molecular interaction kinetics and sinusoidal mechanical properties on leukocyte adhesion in liver sinusoid jointly. Results showed that, within the range of biological limitations, the lumen stenosis ratio, leukocyte stiffness, Disse space stiffness and endothelium permeability regulate the comprehensive adhesion process in a descending order of significance in the presence of receptor-ligand interactions. While leukocyte adhesions could be mutually promoted with proper combinations of leukocyte stiffness, lumen stenosis, and molecular interaction, the binding affinity is insensitive under the conditions with low leukocyte stiffness in normal lumen stenosis and high leukocyte stiffness in high lumen stenosis. This work deepens the understanding of recruitment mechanism of leukocyte in liver sinusoids.

中文翻译：

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分子相互作用和肝脏正弦力学性质对白细胞粘附的影响


有趣的是，病理学上发现白细胞，尤其是中性粒细胞，往往主要粘附在肝窦中，但不粘附在窦后小静脉中。虽然提出了受体-配体相互作用和物理捕获两种观点来介导肝窦中白细胞粘附，但对它们各自贡献进行分类的综合研究却很少。本研究结合蒙特卡洛模拟和浸没边界法，数值研究了分子相互作用动力学和正弦力学性质对肝窦关节中白细胞粘附的影响。结果表明，在生物学限制范围内，在受体-配体相互作用存在下，管腔狭窄比、白细胞刚度、Disse 空间刚度和内皮通透性按显着性降序调节综合粘附过程。虽然白细胞粘附可以通过白细胞刚度、管腔狭窄和分子相互作用的适当组合相互促进，但在正常管腔狭窄中白细胞刚度低和管腔狭窄中白细胞刚度高的情况下，结合亲和力不敏感。这项工作加深了对肝窦中白细胞募集机制的理解。