Oral pre-exposure prophylaxis (PrEP) reduces HIV acquisition risk from sex by 99% and from injection drug use by ≥74% when used as recommended. The Joint United Nations Programme on HIV/AIDS (UNAIDS) has set a goal of 21.2 million persons using (initiating or continuing) PrEP globally in 2025. In 2016, CDC, with the U.S. President's Emergency Plan for AIDS Relief, joined ministries of health to implement PrEP globally. PrEP is beneficial for persons at substantial risk for acquiring HIV, including but not limited to key populations, which include female sex workers, men who have sex with men, persons in prisons and other enclosed settings, persons who inject drugs, and transgender persons. Annual country targets were used to guide scale-up. In 2023, CDC supported 856,816 PrEP initiations, which represents nearly one quarter of the 3.5 million persons globally who either initiated or continued PrEP that year. During 2017-2023, CDC supported PrEP initiations for 2,278,743 persons, 96.0% of whom were in sub-Saharan Africa. More than one half (64.0%) were female and 44.9% were aged 15-24 years. Overall, CDC achieved 118.7% of its PrEP initiation targets for the 7-year period. Among PrEP initiations for key populations, the majority in sub-Saharan Africa were female sex workers, whereas in Southeast Asia, Eurasia, and the Americas, the majority were men who have sex with men. Continued rapid scale-up is needed to meet the UNAIDS goal to end HIV as a public health threat.

中文翻译：

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联合国艾滋病规划署全球 HIV 暴露前预防目标的进展：CDC 支持的口服暴露前预防 - 37 个国家，2017-2023 年。


按照推荐使用时，口服暴露前预防 （PrEP） 可将性行为感染 HIV 的风险降低 99%，注射吸毒的风险降低 ≥74%。联合国艾滋病毒/艾滋病联合规划署 （UNAIDS） 设定了到 2025 年全球 2120 万人使用（开始或持续）PrEP 的目标。2016 年，CDC 与美国总统艾滋病紧急救援计划合作，与卫生部一起在全球范围内实施 PrEP。PrEP 对感染 HIV 的重大风险人群有益，包括但不限于重点人群，包括女性性工作者、男男性行为者、监狱和其他封闭环境中的人、注射吸毒者和跨性别者。年度国家目标被用来指导扩大规模。2023 年，CDC 支持了 856,816 例 PrEP 启动，占当年全球 350 万开始或持续 PrEP 的人的近四分之一。2017-2023 年期间，CDC 为 2,278,743 人提供了 PrEP 启动支持，其中 96.0% 的人在撒哈拉以南非洲。超过一半 （64.0%） 是女性，44.9% 的年龄在 15-24 岁之间。总体而言，CDC 在 7 年期间实现了 118.7% 的 PrEP 启动目标。在重点人群的暴露前预防计划中，撒哈拉以南非洲的大多数是女性性工作者，而在东南亚、欧亚大陆和美洲，大多数是男男性行为者。需要继续快速扩大规模，以实现联合国艾滋病规划署 （UNAIDS） 消除艾滋病毒作为公共卫生威胁的目标。