Enzymes are highly efficient and selective catalysts that operate under mild conditions, making them invaluable for various chemical transformations. However, their limitations, such as instability and high cost, call for advancements in enzyme immobilization and the development of suitable host materials. Metal–organic frameworks (MOFs), characterized by high porosity, crystallinity, and tunability, are promising candidates for enzyme encapsulation. Among these, zirconium-based MOFs (Zr-MOFs) stand out due to their exceptional structural diversity and chemical stability. The physical and chemical properties of Zr-MOFs can be tuned and characterized with atomic precision, and their interactions with enzymes can be analyzed through a range of techniques spanning from chemistry and materials science to biochemistry. This tunable platform provides opportunities to systematically investigate the impact of encapsulation on the stability and activity of enzymes in order to develop design rules for enzyme hosts.

中文翻译：

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增强生物催化：金属-有机框架作为多功能酶宿主


酶是高效和选择性的催化剂，可在温和的条件下运行，使其在各种化学转化中具有不可估量的价值。然而，它们的局限性，如不稳定性和高成本，要求在酶固定化和开发合适的宿主材料方面取得进展。金属有机框架 （MOF） 具有高孔隙率、结晶度和可调性，是酶包埋的有前途的候选者。其中，锆基 MOF （Zr-MOF） 因其卓越的结构多样性和化学稳定性而脱颖而出。Zr-MOF 的物理和化学性质可以调整并以原子精度表征，并且它们与酶的相互作用可以通过从化学和材料科学到生物化学的一系列技术进行分析。这个可调平台为系统研究包埋对酶稳定性和活性的影响提供了机会，以便为酶宿主开发设计规则。