Exercise has received considerable attention because of its importance not just in regulating physiological function, but also in ameliorating multiple pathological processes. Among these processes, lipolysis may play an important role in exercise-induced benefits. It is generally accepted that active lipolysis contributes to breakdown of fats, leading to the release of free fatty acids (FFAs) that serve as an energy source for muscles and other tissues during exercise. However, the significance of lipolysis in the context of exercise has not been fully understood. This review comprehensively outlines the potential regulatory mechanisms by which exercise stimulates lipolysis. The potential roles of exercise-mediated lipolysis in various physiological and pathological processes are also summarized. Additionally, we also discussed the potential non-classical effects of key lipolytic effectors induced by exercise. This will enhance our understanding of how exercise improves lipolytic function to bring about beneficial effects, offering new insights into potential therapeutic avenues for promoting health and alleviating diseases.

中文翻译：

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运动调节脂肪分解：其在健康和疾病中的作用和机制


运动受到了相当大的关注，因为它不仅在调节生理功能方面很重要，而且在改善多种病理过程方面也很重要。在这些过程中，脂肪分解可能在运动诱导的益处中发挥重要作用。人们普遍认为，活性脂肪分解有助于脂肪分解，导致游离脂肪酸 （FFA） 的释放，这些脂肪酸在运动过程中充当肌肉和其他组织的能量来源。然而，脂肪分解在运动中的重要性尚不完全清楚。本综述全面概述了运动刺激脂肪分解的潜在调节机制。还总结了运动介导的脂肪分解在各种生理和病理过程中的潜在作用。此外，我们还讨论了运动诱导的关键脂肪分解效应器的潜在非经典效应。这将增强我们对运动如何改善脂肪分解功能以产生有益效果的理解，为促进健康和缓解疾病的潜在治疗途径提供新的见解。