Currently, the frontier challenges in total synthesis pertain to increasing the synthetic efficiency and enabling the divergent synthesis of a number of natural products. Bioinspired synthesis has been well recognized as an effective approach to increasing synthetic efficiency. Especially, when bioinspired synthesis was applied at late-stage skeletal diversification to generate various natural products with distinct carbon skeletons, it held special promise for achieving both goals. In our laboratory, bioinspired synthesis has served as one of two long-standing principles for facilitating the efficient synthesis of natural products. In this Account, we summarize our endeavors and journeys in the bioinspired synthesis of natural products. We categorize our work into three parts based on the imitation of biosynthetic reactions and processes.

中文翻译：

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Bioinspired 天然产物全合成


目前，全合成的前沿挑战与提高合成效率和实现多种天然产物的不同合成有关。仿生合成已被公认为提高合成效率的有效方法。特别是，当仿生合成应用于骨骼多样化后期以生成具有不同碳骨架的各种天然产物时，它对实现这两个目标具有特殊的希望。在我们的实验室中，仿生合成已成为促进天然产物高效合成的两项长期原则之一。在这篇报道中，我们总结了我们在天然产物的生物启发合成方面的努力和旅程。我们根据对生物合成反应和过程的模仿将我们的工作分为三个部分。