Previous methods for selective halogenation of aliphatic C–H bonds generally required catalysts, additives, and the use of large amounts of solvents, leading to low atom economy and solvent pollution issues. We report herein a visible-light-driven bromination/chlorination of 3° C(sp³)–H bonds without using any catalyst or solvent. This method can functionalize C–H bonds with high site selectivity and excellent functional group tolerance, even in complex molecules. Additionally, the reaction can be easily scaled up to gram-level production without losing efficiency.

中文翻译：

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一种不含催化剂和溶剂的可见光促进的叔 C（sp3）–H 键的溴化和氯化反应


以前脂肪族 C-H 键的选择性卤化方法通常需要催化剂、添加剂和使用大量溶剂，从而导致原子经济性低和溶剂污染问题。我们在此报道了在不使用任何催化剂或溶剂的情况下，3° C（sp³）–H 键的可见光驱动的溴化/氯化反应。即使在复杂分子中，该方法也可以以高位点选择性和出色的官能团耐受性功能化 C-H 键。此外，该反应可以很容易地放大到克级生产，而不会降低效率。