New α-glycosides of chalcones and dihydrochalcones, analogues of naturally occurring phlorizin, have been synthesized using a CGTase-catalyzed glycosylation that was successfully scaled-up in a 10-liter reactor. The α-glycosides were (i) purified using an original centrifugal partition chromatography technique, (ii) characterized through NMR and LC–MS analyses, and (ii) evaluated for their antioxidant, anti-tyrosinase and antimicrobial activities compared to the non-glycosylated compounds.

中文翻译：

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新型根皮苷类似物的可持续和可扩展的酶生产、结构解析和生物学评价


查耳酮和二氢查耳酮的新型 α-糖苷是天然存在的根皮苷的类似物，已使用 CGTase 催化的糖基化合成，该糖基化在 10 升反应器中成功放大。α-糖苷类药物 （i） 使用原始离心分配色谱技术进行纯化，（ii） 通过 NMR 和 LC-MS 分析进行表征，以及 （ii） 评估其与非糖基化化合物相比的抗氧化、抗酪氨酸酶和抗菌活性。